Independent role of Alzheimer's disease genetics and C-reactive protein on cognitive ability in aging
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open access
Keywords
Alzheimer's disease
Cognitive aging
Polygenic risk scores
APOE
Serum CRP
Pathway-based PRS-LOAD
List of abbreviations
LOAD
Late-onset Alzheimer's disease
APOE
Apolipoprotein
GWAS
Genome-wide association studies
AD
Alzheimer's disease
SNP
Single-nucleotide polymorphism
ADNI study
The Alzheimer's Disease Neuroimaging Initiative
CSF
Cerebrospinal fluid
UKB
UK Biobank
APP
Amyloid precursor protein metabolism/Aß-formation
RCT
Reverse cholesterol transport
CRP
C-reactive protein
PRS-LOAD
Genome-wide polygenic risk score for Late-onset Alzheimer's disease
APP PRS-LOAD
Amyloid precursor protein metabolism/Aß-formation pathway polygenic risk score
Tau PRS-LOAD
Tau protein binding pathway polygenic risk score
Lipids PRS-LOAD
Lipids metabolism pathway polygenic risk score
RCT PRS-LOAD
Reverse cholesterol transport pathway polygenic risk score
Immune PRS-LOAD
Immune response pathway polygenic risk score
LD
Linkage Disequilibrium
ICD-10
International Statistical Classification of Diseases and Related Health Problems 10th Revision
VNR
Verbal number reasoning test
NM
Numeric memory test
VM
Visual memory test
RT
Reaction time test
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© 2023 The Author(s). Published by Elsevier Inc.