Theta burst stimulation of dorsolateral prefrontal cortex modulates pathological language switching: A case report
Research highlights
▶ Neuroimaging studies had highlighted the importance of the DLPFC in language switching. ▶ The nature of language switching and its neural correlates have not been clearly established. ▶ We used TBS in a bilingual patient showing pathologic language switching. ▶ An interruption of language switching occurred after excitatory left DLPFC stimulation. ▶ Inhibitory left DLPFC TBS transiently increased the language switching. ▶ Our findings suggest that left DLPFC is actively involved in language switching. ▶ TMS techniques may help in understanding the neural bases of bilingualism.
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Effects of theta burst stimulation over the dorsolateral prefrontal cortex on language switching – A behavioral and ERP study
2020, Brain and LanguageCitation Excerpt :Neuropsychological cases (Fabbro, Skrap, & Aglioti, 2000; Meuter, Humphreys, & Rumiati, 2002; Nardone et al., 2011) as well as neuroimaging (Hernandez, Dapretto, Mazziotta, & Bookheimer, 2001; Hernandez, Martinez, & Kohnert, 2000; Khateb et al., 2007; Mouthon et al., 2019) and intracranial electric stimulation studies (Lubrano, Prod’homme, Démonet, & Köpke, 2012; Sierpowska et al., 2018, 2013) assume a causal role of the left DLPFC in language control. However, two case studies investigating noninvasive brain stimulation (NIBS) over the left frontal cortex showed deviating effects on language switching (increase versus decrease after excitatory stimulation; Holtzheimer, Fawaz, Wilson, & Avery, 2005; Nardone et al., 2011). Moreover, no study has so far investigated whether the left DLPFC specifically contributes to inhibiting the non-target language.
Involvement of the middle frontal gyrus in language switching as revealed by electrical stimulation mapping and functional magnetic resonance imaging in bilingual brain tumor patients
2018, CortexCitation Excerpt :However, the literature concerning the intraoperative monitoring of LS in multilingual brain tumor patients is rather scarce. Even if the intraoperative evidences on LS are yet to be explored, evidence from other studies using functional magnetic resonance imaging (fMRI) (Abutalebi et al., 2008; Chee, Soon, & Lee, 2003; Hernandez, 2009; Hernandez, Dapretto, & Mazziotta, 2001; Hernandez, Martinez, & Kohnert, 2000; Luk, Green, Abutalebi, Grady, & Edu, 2011; Rodriguez-Fornells et al., 2002), electroencephalography (EEG) (Khateb et al., 2007; Kuipers & Thierry, 2010; Moreno, Federmeier, & Kutas, 2002; Proverbio, Leoni, & Zani, 2004) and transcranial magnetic stimulation (TMS) (Holtzheimer, Fawaz, Wilson, & Avery, 2005; Nardone et al., 2011) support the idea that LS, similarly as task switching, is sustained (at least partially) by a more general executive control system (Fabbro, 2001; Guo, Liu, Misra, & Kroll, 2011; Hernandez et al., 2001; Hervais-Adelman, Moser-Mercer, & Golestani, 2011; Rodriguez-Fornells, De Diego Balaguer, & Münte, 2006). However, there is still no agreement concerning the brain regions selectively recruited during LS.
Left middle temporal and inferior frontal regions contribute to speed of lexical decision: A TMS study
2015, Brain and CognitionCitation Excerpt :Indeed, TMS has been successfully used to investigate neural underpinnings of language (Cattaneo, Devlin, Salvini, Vecchi, & Silvanto, 2010; Cattaneo, Devlin, Vecchi, & Silvanto, 2009; Devlin & Watkins, 2007; Pulvermuller & Fadiga, 2010). For instance, suppression of language production has been reported when the left lateral prefrontal cortex was stimulated (Nardone et al., 2011) by continuous theta-burst TMS (Huang, Edwards, Rounis, Bhatia, & Rothwell, 2005). A secondary aim of the present study was to address the issue of whether aLIFG and LMTG may play slightly different roles in word recognition by incorporating a semantic priming paradigm within our design.
Altered functional connectivity of the language network in ASD: Role of classical language areas and cerebellum
2014, NeuroImage: ClinicalCitation Excerpt :Those results strongly support the hypothesis that the cortical functioning of Broca's area is not affected per se, but that language dysfunction in ASD-LI is the result of a dysfunctional regulatory control of this region. The significantly reduced functional connectivity between Broca's area and DLPF, which is an important modulatory area for language, together with an intact Broca–Wernicke connection, further supports this hypothesis (Kovelman et al., 2012; Nardone et al., 2011; Romanski et al., 1999). Secondly, we correlated our behavioral measures with the connectivity strengths in those language related ROI-pairs that showed significant group differences.
Intraoperative electrical stimulation of language switching in two bilingual patients
2013, NeuropsychologiaCitation Excerpt :Similarly, it has been shown that transcranial magnetic stimulation (TMS) applied to the MFG (more precisely to the left dorsolateral prefrontal cortex—DLPFC) can induce involuntary LS (Holtzheimer, Fawaz, Wilson, & Avery, 2005). Moreover, a lesion study of a patient who suffered an ischemic stroke in the aforementioned structure (DLPFC) and presented pathological switching further supports the importance of this region in LS (Nardone et al., 2011). In line with these findings, an enhanced activation in the posterior inferior frontal region has also been revealed in an fMRI study using an LS-related task in bilinguals (Rodriguez-Fornells, Rotte, Heinze, Nosselt, & Münte, 2002).