Effect of mild hypothermia on angiogenesis in rats with focal cerebral ischemia
Section snippets
Acknowledgements
We thank Soon-Tae Lee and Jae-Kyu Roh for their technical assistance. We also thank Bo-Qun Pan for his assistance with confocal microscopy.
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2018, NeuropharmacologyCitation Excerpt :How hypothermia affects gliogenesis has not yet been completely clarified, although there is one report (Kurisu et al., 2016a) showing that hypothermia prevents post-ischemic reactive gliosis and glial scar formation. Mild hypothermia has been shown to enhance angiogenesis in several brain injury models (Kuo et al., 2010; Xie et al., 2007). Although this effect of enhanced angiogenesis by hypothermia is presumably beneficial to the repair processes (Yenari and Han, 2012), its significance is still unclear.
Therapeutic hypothermia for stroke: Where to go?
2015, Experimental NeurologyCitation Excerpt :Although scientific literature regarding the role of hypothermia in neuronal connectivity repair after ischemia is scarce, it was proved that hypothermia would enhance neurite outgrowth in vitro, and upregulate genes involved in synapse organization in rat models of traumatic brain injury (Feng et al., 2010; Schmitt et al., 2010). Mild hypothermia has also been shown to enhance angiogenesis in focal cerebral ischemia, and increased the number of oligodendrocyte precursor cells in a primary culture taken from embryonic mouse brains (Imada et al., 2010; Xie et al., 2007). Thus, hypothermia exerts neuroprotection through a variety of mechanisms following ischemia (Fig. 1).
Adult neurogenesis and brain remodelling after brain injury: From bench to bedside?
2015, Anaesthesia Critical Care and Pain MedicineCitation Excerpt :In the developing brain, a temperature of 30 °C decreased the number of proliferating cells in the SGZ [55], whereas in other hypoxic conditions, hypothermia (33 °C) enhanced maturation of neuronal progenitor cells in the striatum [56]. Neuronal connectivity, angiogenesis and gliogenesis are stimulated by hypothermic conditions [57–61]. Although the effect of hypothermia in brain regeneration is far from clear, it seems to have beneficial effects and more research is needed in this area to reach any kind of conclusion.
Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model
2014, Journal of the Neurological SciencesCitation Excerpt :The brain sections were analyzed with a laser-scanning confocal imaging system. Eight brain regions in the ischemic boundary zone were selected within a reference coronal section (interaural 8.8 mm, bregma 0.8 mm) [19]. Vascular surface area (mm2) was calculated by Image-Pro Plus software, and the number of vascular branch points was counted in the microscope by a blinded investigator.
Hypoxic ischaemic hypothermia promotes neuronal differentiation and inhibits glial differentiation from newly generated cells in the SGZ of the neonatal rat brain
2012, Neuroscience LettersCitation Excerpt :NSC differentiation is regulated by local micro-environmental factors including the vasculature growth factors and multiple cell types such as astrocytes, endothelial cells and local mature neurons [17,36]. The elevated angiogenesis [32], brain-derived neurotrophic factor [34] and vascular endothelial growth factor [6] expression in hypothermia-treated animals may provide a local microenvironment that promotes neuronal differentiation in hypothermic conditions after HI. In summary, the findings from the present study indicate that hypothermia promotes neuronal over glial differentiation from newly generated cells in the SGZ of the neonatal rat brain after hypoxia–ischaemia.
Hypoxic-Ischemic Encephalopathy in the Term Infant
2009, Clinics in PerinatologyCitation Excerpt :Although several different agents have shown a neuroprotective effect in animal models of HI, hypothermia is the only therapeutic intervention that has been extensively investigated in the newborn patient population.8,150–153 This clinical investigation was preceded by a large number of preclinical studies in multiple animal models that demonstrated a neuroprotective effect.90,154–159 Clinical studies have shown an overall reduction in mortality accompanied by a reduction in disability among newborns with HIE who were enrolled in hypothermia protocols within the first day of life.9