Decrease in haemoglobin oxygenation during absence seizures in adult humans
Section snippets
Acknowledgements
This study was supported by the DFG: Klinische Forschergruppe “Neue Methoden zur nicht-invasiven Funktions-Diagnostik des ZNS” and the DFG grant BU 1331-1
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2024, Journal of ProteomicsFurther improvement in reducing superficial contamination in NIRS using double short separation measurements
2014, NeuroImageCitation Excerpt :The results presented in this paper suggest that real benefits are obtained using two SS measurements compared to using a single one. These benefits are significant in cases where only a few trials can be performed such as in clinical studies (Buchheim et al., 2004; Haginoya et al., 2002; Machado et al., 2010; Wallois et al., 2010). However, in cases where several trials can be averaged, using a single SS detector located close to the source might be sufficient and less troublesome.
NIRS in clinical neurology - a 'promising' tool?
2014, NeuroImageCitation Excerpt :Supporting the idea of a deoxygenation in generalized seizures 3 patients with absence seizures showed a deoxygenation (HbO↓, HbR↑) over the frontal lobe. This is discussed to indicate either generalized ‘deactivation’ during this seizure type or a pathological mismatch between oxygen demand and supply in generalized seizures (Buchheim et al., 2004). The pattern of a deoxygenation in response to generalized epileptic activity is also supported by a study of electroconvulsive therapy (ECT).
Advantages and limitations of brain imaging methods in the research of absence epilepsy in humans and animal models
2013, Journal of Neuroscience MethodsNonlinear hemodynamic responses in human epilepsy: A multimodal analysis with fNIRS-EEG and fMRI-EEG
2012, Journal of Neuroscience MethodsCitation Excerpt :Thus it is of interest to use fNIRS to unravel how much of a BOLD signal comes from HbR and blood volume changes and, indeed, various types of responses have been reported. Supporting results from fMRI-EEG, there are reports with fNIRS of inverted responses (HbO decrease and HbR increase) (Buchheim et al., 2004), responses prior to events on scalp EEG in an animal model of spikes (Osharina et al., 2010) (however this effect was not seen in Vanzetta et al., 2010) and a long time of return to baseline. Existence of these 3 phenomena was further confirmed recently in our group's patient data (Nguyen et al., in press).
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These authors contributed equally to this work.