ReviewAdaptation of the human population to the environment: Current knowledge, clues from Czech cytogenetic and “omics” biomonitoring studies and possible mechanisms
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Abbreviations
5mC
5-methyl-cytosine
AHR2
aryl hydrocarbon receptor 2
AS3MT
arsenic (+3 oxidation state) methyltransferase
B[a]P
benzo[a]pyrene
BER
base excision repair
BNC
binucleated cell
c-PAHs
carcinogenic polycyclic aromatic hydrocarbons
CBMN assay
cytokinesis-block micronucleus assay
CEN-MN
micronuclei with the absence of centromere signal
CEN+MN
micronuclei with the presence of centromere signal
Cy-3
cyanine 3
DAPI
4´-6-diamidino-2-phenylindole
FG/100
genomic frequency of translocations/100 cells
FISH
fluorescent in situ hybridization
FITC
fluorescein-5-isothiocyanate
KEGG
Kyoto Encyclopedia of Genes and Genomes
MN
micronuclei
MNNG
N-methyl-N'-nitro-N-nitrosoguanidin
MTase
methyltransferase
NHEJ
non-homologous end-joining
PAR
predictive adaptive response
PCA
principal component analysis
PBL
peripheral blood lymphocytes
PCBs
polychlorinated biphenyls
XRCC SNP
single nucleotide polymorphism X-ray repair complementing defective repair in Chinese hamster cells
WGBS
whole-genome bisulfite sequencing
Keywords
Adaptive response
DNA methylation
Environmental exposure
Micronuclei
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© 2017 The Authors. Published by Elsevier B.V.