Elsevier

Journal of Molecular Liquids

Volume 240, August 2017, Pages 678-681
Journal of Molecular Liquids

Short Communication
Further calculations on solubility of 2-chloro-3-(trifluoromethyl)pyridine in ethanol + 1-propanol solvent mixtures at various temperatures

https://doi.org/10.1016/j.molliq.2017.05.117Get rights and content

Highlights

  • CNIBS/R-K describes observed solubility data to average MRD of 1.2%.

  • Combined Jouyban-Acree and van't Hoff model describes solubility data to average MRD of 2.1%.

  • Inverse Kirkwood-Buff treatment shows no preferential solvation of solvents around dissolved solute.

Abstract

The reported calculations on solubility data of 2-chloro-3-(trifluoromethyl)pyridine in binary ethanol + 1-propanol solvent mixtures at various temperatures have been reanalyzed and several additional points regarding the correlations were reported. In addition preferential solvation of 2-chloro-3-(trifluoromethyl)pyridine in ethanol + 1-propanol mixtures were investigated by means of the inverse Kirkwood-Buff integrals method. Apparently no preferential solvation of this compound by both organic solvents is observed because the respective parameters are lower than 0.01 in all the analyzed compositions.

References (35)

  • A. Jouyban et al.

    Comments on “Solubility and solution thermodynamics of 2,3,4,5-tetrabromothiophene in (ethanol + trichloromethane) binary solvent mixtures”

    Fluid Phase Equilib.

    (2016)
  • S.H. Yalkowsky et al.

    Solubilization of drugs by cosolvents

  • A. Jouyban

    Review of the cosolvency models for predicting solubility of drugs in water-cosolvent mixtures

    J. Pharm. Pharm. Sci.

    (2008)
  • A. Jouyban et al.

    Solubility prediction of paracetamol in water–glycerol mixtures at 25 and 30 °C using the Jouyban–Acree model

    Asian J. Chem.

    (2009)
  • A. Jouyban et al.

    Solubility of chlordiazepoxide, diazepam, and lorazepam in ethanol + water mixtures at 303.2 K

    J. Chem. Eng. Data

    (2009)
  • A. Jouyban et al.

    Comments on “Solubility of ethyl maltol in aqueous ethanol mixtures” (Liu, B.-S.; Liu, R.-J.; Hu, Y.-Q.; Hu, Q.-F. J. Chem. Eng. Data 2008, 53, 2712–2714)

    J. Chem. Eng. Data

    (2009)
  • S. Ahmadian et al.

    Solubility of phenothiazine in water, ethanol, and propylene glycol at (298.2 to 338.2) K and their binary and ternary mixtures at 298.2 K

    J. Chem. Eng. Data

    (2011)
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