The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension

doi:10.1016/j.molcel.2020.11.022

Molecular Cell

Volume 80, Issue 5, 3 December 2020, Pages 760-761

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Takahashi et al. (2020) conduct a focused CRISPR/Cas9 screen against NRF2 target and other redox regulatory genes in both 2D- and 3D-culture systems, uncovering a vulnerability of spheroid cancer cells deprived of extracellular matrix to undergo ferroptosis.

Molecular Cell

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The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension