Molecular Cell
Volume 69, Issue 5, 1 March 2018, Pages 721-723
Journal home page for Molecular Cell

Preview
SCF E3 Ligase Substrates Switch from CAN-D to Can-ubiquitylate

https://doi.org/10.1016/j.molcel.2018.02.019Get rights and content
Under an Elsevier user license
open archive

Liu et al. (2018) report a mathematical model predicting how the cellular repertoire of SCF E3 ligases is assembled by “adaptive exchange on demand,” with the limited pool of CUL1 scanning the vast sea of F-box proteins for those with substrates demanding ubiquitylation.

Cited by (0)