Molecular Cell
Volume 42, Issue 1, 8 April 2011, Pages 75-83
ArticleEssential Role for Ubiquitin-Ubiquitin-Conjugating Enzyme Interaction in Ubiquitin Discharge from Cdc34 to Substrate
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Graphical Abstract
Highlights
► Ubiquitin-I44A mutation is defective in thioester discharge from Cdc34 to substrate ► Ub-I44A thioester discharge defect can be rescued by compensatory mutations in Cdc34 ► Interaction between donor Ub and Cdc34 is critical for efficient thioester discharge ► Discharge defect of Ub-I44A is due to inefficient deprotonation of acceptor lysine
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These authors contributed equally to this work
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