Molecular Cell
Volume 41, Issue 3, 4 February 2011, Pages 343-353
ArticleSecA Interacts with Ribosomes in Order to Facilitate Posttranslational Translocation in Bacteria
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Highlights
► SecA binds directly to ribosomes near the polypeptide exit channel ► Binding involves conserved residues in ribosomal protein L23 and SecA ► Disruption of the SecA-ribosome interaction causes a protein translocation defect ► SecA binds with increased affinity specifically to ribosomes containing substrates
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Present address: Department of Biology, University of Konstanz, D-78457 Konstanz, Germany
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Present address: Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA
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Present address: Molecular Partners AG, Wagistrasse 14, CH-8952 Schlieren-Zurich, Switzerland
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