Molecular Cell
Volume 38, Issue 3, 14 May 2010, Pages 345-355
ArticleInitiation of the TORC1-Regulated G0 Program Requires Igo1/2, which License Specific mRNAs to Evade Degradation via the 5′-3′ mRNA Decay Pathway
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Highlights
► Initiation of the TORC1-regulated G0 program requires Igo1 and Igo2 ► TORC1 inhibition triggers phosphorylation of Igo1/2 by the protein kinase Rim15 ► Activated Igo1/2 shelter specific mRNAs from entry into the 5′-3′ mRNA decay pathway ► The likely conserved function of Igo1/2 is key for cell differentiation and life span
SIGNALING
RNA
CELLCYCLE
Cited by (0)
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These authors contributed equally to this work
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Present address: Institute of Cell Biology, University of Bern, CH-3012, Bern, Switzerland
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