Elsevier

Microbiological Research

Volume 214, September 2018, Pages 123-128
Microbiological Research

Role of two-component regulatory systems in the virulence of Streptococcus suis

https://doi.org/10.1016/j.micres.2018.07.002Get rights and content
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Abstract

Streptococcus suis is an important zoonotic pathogen that causes severe infections and great economic losses worldwide. Understanding how this pathogen senses and responds to environmental signals during the infectious process can offer insight into its pathogenesis and may be helpful in the development of drug targets. Two-component regulatory systems (TCSs) play an essential role in this environmental response. In S. suis, at least 15 groups of TCSs have been predicted. Among them, several have been demonstrated to be involved in virulence and/or stress response. In this review, we discuss the progress in the study of TCSs in S. suis, focusing on the role of these systems in the virulence of this bacterium.

Keywords

Two-component regulatory systems
Streptococcus suis
Virulence

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