Elsevier

Microbes and Infection

Volume 17, Issue 2, February 2015, Pages 123-134
Microbes and Infection

Advancements in the development of subunit influenza vaccines

https://doi.org/10.1016/j.micinf.2014.12.006Get rights and content
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Abstract

The ongoing threat of influenza epidemics and pandemics has emphasized the importance of developing safe and effective vaccines against infections from divergent influenza viruses. In this review, we first introduce the structure and life cycle of influenza A viruses, describing major influenza A virus-caused pandemics. We then compare different types of influenza vaccines and discuss current advancements in the development of subunit influenza vaccines, particularly those based on nucleoprotein (NP), extracellular domain of matrix protein 2 (M2e) and hemagglutinin (HA) proteins. We also illustrate potential strategies for improving the efficacy of subunit influenza vaccines.

Keywords

Influenza A virus
Subunit vaccines
Nucleoprotein
Matrix protein
Hemagglutinin

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