Elsevier

Medical Hypotheses

Volume 108, October 2017, Page 51
Medical Hypotheses

Whether 25 mM of metformin is achievable in human gut from a therapeutic dose of metformin?

https://doi.org/10.1016/j.mehy.2017.08.002Get rights and content

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Conflict of interest

The authors declare that they have no conflict of interest.

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Cited by (3)

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    Citation Excerpt :

    Pharmacokinetic studies in animals [6] and PET scans in humans suggest that metformin, even after absorption, concentrates in the intestines predominantly [148]. It has been recently suggested that mM concentrations of metformin are plausible in the intestinal lumen and that may explain some of the metformin’s actions [160]. The luminal concentrations of butyrate are in the mM range as well [10,11].

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