Residents' clinic23-Year-Old Man With Jaundice and Elevated Liver Enzymes
Section snippets
Discussion
Idiopathic hepatitis-associated AA is a disease characterized by acute and usually severe liver disease with a recovery phase. During or after this recovery phase, patients may develop AA, although it is typically seen weeks or even years later7, 11, 12 and is usually first noticed as progressive pancytopenia. The symptoms include pallor, skin bleeding, fatigue, dizziness, and severe infection. A thorough workup is required since IHAAA is a diagnosis of exclusion, with severe and otherwise
Conclusion
Idiopathic hepatitis-associated AA is a serious and potentially life-threatening condition in which progressive pancytopenia may develop weeks or even months after an initial recovery phase. Prompt treatment with IST and HSCT can substantially improve outcomes.
References (12)
Anemia in adults: a contemporary approach to diagnosis
Mayo Clin Proc
(2003)- et al.
Screening for Wilson disease in acute liver failure: a comparison of currently available diagnostic tests
Hepatology
(2008) - et al.
Acute liver failure
N Engl J Med
(2013) - et al.
Evaluation of abnormal liver function tests
Postgrad Med J
(2003) - et al.
Drug-induced liver injury
Arch Pathol Lab Med
(2015) - et al.
Aplastic anemia in adolescents and young adults
Acta Haematol
(2014)
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Potential Competing Interests: The authors report no competing interests.
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