The old guard: Age-related changes in microglia and their consequences
Under a Creative Commons license
open access
Abbreviations
AD
Alzheimer’s Disease
AHR
aryl hydrocarbon receptor
BAM
barrier-associated macrophages
BBB
blood-brain barrier
CCL2
C-C motif chemokine ligand 2
CR
caloric restriction
CRP
c-reactive protein
CSF1R
colony stimulating factor 1 receptor
C1q
complement component 1q
C3
complement component
DAM
disease-associated microglia
DC
dendritic cell
DHA
docosahexaenoic acid
EPA
eicosapentaenoic acid
FTLD
frontotemporal lobar degeneration
GC
glucocorticoids
HAM
human Alzheimer’s disease microglia
HFD
high-fat diet
HMGB1
high mobility group box protein 1
HPA axis
hypothalamic-pituitary-adrenal axis
HSV1
herpes simplex virus 1
IBA-1
ionized calcium-binding adaptor protein 1
IFA
interfollicular area
IFN-I
interferon type 1
IFN-III
interferon type 3
IFN-β
interferon beta
IFN- γ
interferon gama
IL-6
interleukin 6
IL-1β
interleukin 1beta
IL-4
interleukin 4
IL-8
interleukin 8
IL-12
interleukin 12
IL-10
interleukin 10
IL-17
interleukin 17
LDAM
lipid-droplet accumulating microglia
LPS
lipopolysaccharide
M-CSF
macrophage colony-stimulating factor
MGnD
microglial neurodegenerative phenotype
MHCII
major histocompatibility complex class II
MIA
maternal immune activation
mPFC
medial prefrontal cortex
NF-Kb
nuclear factor kappa B
NK
natural killer cells
n-3 PUFAs
omega-3 polyunsaturated fatty acids
OPCs
oligodendrocyte progenitor cells
pDCs
plasmacytoid dendritic cells
P3C
pam3CysSerLys4ROS - reactive oxygen species
SASP
senescence-associated secretory phenotype
TCR
T cell receptor
TDP-43
TAR DNA-binding protein 43
TGF-β
transforming growth factor β
Th2
helper T cells type 2
TLR
toll-like receptor
TNF-α
tumor necrosis factor α
TREM1
triggering receptor expressed on myeloid cells 1
TSPO
translocator protein
Keywords
Aging
Stress
Infection
Cognitive decline
Neuroimmune system
Microglia
Inflammation
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© 2021 The Author(s). Published by Elsevier B.V.