EGFR mutation detection in ctDNA from NSCLC patient plasma: A cross-platform comparison of leading technologies to support the clinical development of AZD9291
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Abbreviations
ARMS
amplification refractory mutation system
BEAM
beads, emulsions, amplification, and magnetics
CR
complete response
ctDNA
circulating tumor DNA
dPCR
digital polymerase chain reaction
ddPCR
Droplet Digital PCR
EGFR
epidermal growth factor receptor
M1a/M0
disease confined to the thoracic cavity
M1b
extra-thoracic metastatic disease
NSCLC
non-small cell lung cancer
PCR
polymerase chain reaction
PR
partial response
SD
stable disease
TKI
tyrosine kinase inhibitor
Keywords
Non-small cell lung cancer
Circulating tumor DNA
Epidermal growth factor receptor mutation
T790M
AZD9291
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Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.