Chenodeoxycholic acid significantly impacts the expression of miRNAs and genes involved in lipid, bile acid and drug metabolism in human hepatocytes
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Abbreviations
ABC
ATP-binding cassette transporter
AGPAT2
1-acylglycerol-3-phosphate O-acyltransferase
AhR
arylhydrocarbon receptor
AKR1C1
aldo-keto reductase 1C1
APO
apolipoprotein
ASBT
apical sodium dependent bile acid transporter
BAs
bile acids
BSEP
bile salt export pump
CDCA
chenodeoxycholic acid
CPT1A
carnitine palmitoyltransferase 1A
CYP
cytochrome P450
DM
drug metabolism
DMSO
dimethyl sulfoxide
FABP
fatty acid-binding protein
FASN
fatty acid synthase gene
FDR
false discovery rate
FXR
farnesoid X receptor
HMGCS2
3-hydroxy-3-methylglutaryl-CoA synthase 2
LDLR
low density lipoprotein receptor
mRNA
messenger RNA
miRNA
microRNA
NAFLD
nonalcoholic fatty liver disease
NASH
nonalcoholic steatohepatitis
NPC1L1
Niemann-Pick C1-like 1 gene
NTCP
Na+-taurocholate cotransporting polypeptide
OATP
organic anion transport protein
OST
organic solute transporter
PCR
polymerase chain reaction
PHHs
primary human hepatocytes
PPAR-γ
peroxisome proliferator-activated receptor
RT-PCR
real-time PCR
S1PR
sphingosine-1-phosphate receptor
SHP
small heterodimer partner
SLC
solute carrier family
STARD3
StAR-related lipid transfer domain protein 3
SULT
sulfotransferase
UGT
UDP-glucuronosyltransferase
UTR
untranslated region
Keywords
Bile acids
Chenodeoxycholic acid
Primary human hepatocytes
mRNA profiling
microRNA profiling
microRNA-34a
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© 2016 The Authors. Published by Elsevier Inc.