Elsevier

Kidney International

Volume 91, Issue 6, June 2017, Pages 1269-1271
Kidney International

Commentary
ACE2 as therapy for glomerular disease: the devil is in the detail

https://doi.org/10.1016/j.kint.2017.04.001Get rights and content
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Angiotensin-converting enzyme 2 cleaves angiotensin (Ang) II to Ang(1-7), which antagonizes the deleterious effects of Ang II. In this issue, 2 groups administered angiotensin-converting enzyme 2 in murine models of kidney disease. Angiotensin-converting enzyme 2 did not improve glomerular injury in 2 models of mild diabetic nephropathy but was partially protective in an Alport syndrome model. These discrepant findings may be explained by the inability of angiotensin-converting enzyme 2 to reach the urinary space in the absence of severe proteinuria.

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see basic research on pages 1336 and 1347