Laboratory Investigation
Comparison of Bolus Versus Dual-Syringe Administration Systems on Glass Yttrium-90 Microsphere Deposition in an In Vitro Microvascular Hepatic Tumor Model

https://doi.org/10.1016/j.jvir.2022.07.032Get rights and content
Under a Creative Commons license
open access

Abstract

Purpose

To utilize an in vitro microvascular hepatic tumor model to compare the deposition characteristics of glass yttrium-90 microspheres using the dual-syringe (DS) and traditional bolus administration methods.

Materials and Methods

The microvascular tumor model represented a 3.5-cm tumor in a 1,400-cm3 liver with a total hepatic flow of 160 mL/min and was dynamically perfused. A microcatheter was placed in a 2-mm artery feeding the tumor model and 2 additional nontarget arteries. Glass microspheres with a diameter of 20–30 μm were administered using 2 methods: (a) DS delivery at a concentration of 50 mg/mL in either a single, continuous 2-mL infusion or two 1-mL infusions and (b) bolus delivery (BD) of 100 mg of microspheres in a single 3-mL infusion.

Results

Overall, the degree of on-target deposition of the microspheres was 85% ± 11%, with no significant differences between the administration methods. Although the distal penetration into the tumor arterioles was approximately 15 mm (from the second microvascular bifurcation of the tumor model) for all the cases, the distal peak particle counts were significantly higher for the DS delivery case (approximately 5 × 105 microspheres achieving distal deposition vs 2 × 105 for the BD case). This resulted in significantly higher deposition uniformity within the tumor model (90% for the DS delivery case vs 80% for the BD case, α = 0.05).

Conclusions

The use of this new in vitro microvascular hepatic tumor model demonstrated that the administration method can affect the deposition of yttrium-90 microspheres within a tumor, with greater distal deposition and more uniform tumor coverage when the microspheres are delivered at consistent concentrations using a DS delivery device. The BD administration method was associated with less favorable deposition characteristics of the microspheres.

Abbreviations

BD
bolus delivery
DS
dual-syringe
HCC
hepatocellular carcinoma
ID
inner diameter
PHA
proper hepatic artery
PRU
peripheral resistance units
TARE
transarterial radioembolization
90Y
yttrium-90

Cited by (0)

R.J.A. is the cofounder, a shareholder, and an employee (Chief Medical Officer) of ABK Biomedical Inc.; was involved with protocol development, data analysis, review, and editing of the manuscript; and received funding for the research conducted as well as bland and 90Y radiopaque microspheres and microsphere delivery systems from ABK Biomedical Inc. G.D.B. received funding from ABK Biomedical Inc. to conduct this study. None of the other authors have identified a conflict of interest.

From the Global Embolization Symposium & Technologies 2021, “Novel hepatic tumor microvascular model for evaluating the embolic charactersitics of Y-90 microspheres.” J Vasc Interv Radiol, 2021; 32(8): e33-e53