Laboratory InvestigationDual-Energy CT–Derived Volumetric Iodine Concentration for the Assessment of Therapeutic Response after Microwave Ablation in a Rabbit Model with Intrahepatic VX2 Tumor
Section snippets
Animal Care
All experiments were approved by the animal care committee of our institution and performed in compliance with institutional guidelines. Ten male New Zealand White rabbits (aged 3–4 mo, weighing 2–2.5 kg; purchased from the department of laboratory animals of the study institution) were used in the study. The rabbits were housed in individual cages under controlled laboratory conditions with a temperature of 22°C ± 1 and air humidity of 55%. The lights were on for 12 hours every day, and the
Quantitative Response Assessment Measurement
The diameter of the viable tumor, CT density, and VIC at baseline and follow-up are shown in Table 2. The tumor diameters were significantly increased (P = .010). The mean CT density and mean VIC decreased from baseline to follow-up, but not significantly (P = .051 and P = .238, respectively).
Comparison of Different Evaluation Results
The results of response assessment using the different criteria are shown in Table 3. The disease control rate was significantly higher with the use of VIC changes versus mRECIST (P = .033). No significant
Discussion
The present study showed that dual-energy CT–derived VIC change is the imaging assessment method that more closely replicated pathologic findings after MW ablation compared with mRECIST and Choi criteria. VIC showed a better correlation with technical success than diameter or CT density did, and has the potential to be a better tumor response biomarker for MW ablation in patients with HCC.
A previous study (23) showed that volumetric iodine uptake could be used in assessing tumor response to
References (30)
- et al.
Percutaneous ablation of hepatocellular carcinoma: current status
J Vasc Interv Radiol
(2010) - et al.
Current management of hepatocellular carcinoma
Med Clin North Am
(2009) - et al.
Treatment response after radioembolisation in patients with hepatocellular carcinoma-An evaluation with dual energy computed-tomography
Eur J Radiol Open
(2016) - et al.
Comparison of two different methods for inoculating VX2 tumors in rabbit livers and hind limbs
J Vasc Interv Radiol
(2008) - et al.
Quantitative therapy response assessment by volumetric iodine-uptake measurement: initial experience in patients with advanced hepatocellular carcinoma treated with sorafenib
Eur J Radiol
(2013) - et al.
Imaging after radiofrequency ablation of hepatic tumors
Semin Ultrasound CT MR
(2009) - et al.
CT-based response assessment of advanced gastrointestinal stromal tumor: dual energy CT provides a more predictive imaging biomarker of clinical benefit than RECIST or Choi criteria
Eur J Radiol
(2013) - et al.
The minimal ablative margin of radiofrequency ablation of hepatocellular carcinoma (> 2 and < 5 cm) needed to prevent local tumor progression: 3D quantitative assessment using CT image fusion
AJR Am J Roentgenol
(2010) - et al.
Principles of and advances in percutaneous ablation
Radiology
(2011) - et al.
Post-treatment imaging of liver tumours
Cancer Imaging
(2007)
Evaluation of tumor response after locoregional therapies in hepatocellular carcinoma: are response evaluation criteria in solid tumors reliable?
Cancer
EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma
J Hepatol
Comparison of tumor response by Response Evaluation Criteria In Solid Tumors (RECIST) and modified RECIST in patients treated with sorafenib for hepatocellular carcinoma
Cancer
Which response criteria best help predict survival of patients with hepatocellular carcinoma following chemoembolization? A validation study of old and new models
Radiology
Radiologic measurements of tumor response to treatment: practical approaches and limitations
Radiographics
Cited by (9)
Advanced CT techniques for hepatic microwave ablation zone monitoring and follow-up
2022, Abdominal RadiologyA Review of Imaging Methods to Assess Ultrasound-Mediated Ablation
2022, BME FrontiersGastrointestinal Imaging: Oncology (Liver, Pancreas, Bowel Cancer, and Treatment Response)
2022, Medical RadiologyA novel rabbit fixator made of a thermoplastic mask for awake imaging experiments
2021, Scientific Reports
L.Z. and N.W. contributed equally to this work.
X.D. and B.F. contributed equally to this work.
None of the authors have identified a conflict of interest.