Original researchEpidemiological study of post-traumatic ankle osteoarthritis after ankle sprain in 195,393 individuals over middle age using the National Health Insurance Database: A retrospective design
Section snippets
Practical implications
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Early rehabilitation is necessary after an onset of ankle sprain to prevent further development to post-traumatic ankle OA.
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Personalized intervention may be needed considering their gender and BMI to effectively decrease ankle OA risk after a sprain incidence.
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Physical exercise neither increases nor decreases the likelihood of getting diagnosed with ankle OA. Hence further clinical research is necessary to find proper exercise program after ligament injuries.
Methods
We used a sample cohort dataset provided by the Korean National Health Insurance Sharing Service (NHISS).21 The National Health Insurance Corporation (NHIC) manage insurance data for all South Korean citizens and has enabled access to their data from 2002 and on, for the purpose of research on health improvement issues. We used a “sample cohort database” consisting of 448,754 randomly selected individuals of age 40 or older using a stratified sampling method according to gender, age, status of
Results
This population consisted of 115,029 (58.9%) males and 80,364 (41.1%) females. Among the whole population of 195,393 individuals, 40,876 (20.9%) were diagnosed with an ankle sprain, and 1543 (3.85%) of those individuals developed ankle OA within the 11-year follow-up period. Similarly, of the 154,517 healthy individuals (79.1%), 4062 (2.66%) cases had progressed to OA by December 2013. The demographic characteristics of the sprained and healthy populations are presented in Table 1.
The sprained
Discussion
Our major finding is that individuals who had one or more sprain history along the 11-year study period had a significantly greater disease rate of being diagnosed with ankle OA than did healthy people with no sprains. The analysis with sprained population showed that female, overweight, and obese populations were each more likely to develop ankle OA than were the counterpart male and normal-weight populations respectively.
Ankle OA development rate after sprain was 3.85% within the 11-year
Conclusion
In the present study, we found that ankle sprain was a significant risk factor for a diagnosis of early OA. Female gender and high BMI increased the incidence of ankle PTOA after a sprain. As a result, we expect that these results will offer new knowledge to clinicians and trainers for the development of treatment strategies after an ankle sprain and the prevention of further aggravation of cartilage disease.
Funding information
This study was supported by the Ministry of Education and the National Research Foundation of Korea (NRF2015S1A5B8036349).
Declaration of interest statement
None.
Confirmation of ethical compliance
This study was approved by the Yonsei University Institutional Review Board (IRB No.: 7001988-201803-HR-330-01E).
Acknowledgments
This study was supported by the Ministry of Education and the National Research Foundation of Korea (NRF2015S1A5B8036349).
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