Social deficits induced by peripubertal stress in rats are reversed by resveratrol
Section snippets
Animals
The experimental subjects were the offspring of Wistar Han rats (Charles River Laboratories, L'Arbresle, France), bred in our animal house (behavioral experiment, n = 36; neurochemical assays, n = 20). As is our usual practice, at weaning male rats from different litters were mixed throughout the different home cages by placing equivalent numbers of animals from each litter into the different experimental groups and by avoiding having siblings in the same home cage. They were housed three per
Resveratrol normalizes the social investigation deficit induced by peripubertal stress
The beneficial, normalizing effect of resveratrol on the social investigation deficit can be seen in Fig. 1. A three-way ANOVA with Stress and Drug as between-subjects variables and Target as a within-subjects variable was conducted to determine whether there was an effect of resveratrol administration on the exploration of the social and inanimate target cues, according to peripubertal experience. Prior to running the ANOVAs, it was found that some of the assumptions were not met [normality
Discussion
Social relations have pervasive repercussions on health, well beyond the social interactions themselves, and their quality can depend on environmental and temperamental factors, such as sociability (Berkman et al., 2000, Cohen, 2004, House et al., 1988, Uchino, 2006). Here, using rats as the model system, we confirm that exposure to stress during the peripubertal period results in deficient social motivation at adulthood, with exploration levels similar to those previously reported (Márquez
Acknowledgments
We would like to thank Vandana Veenit for assistance with the peripubertal stress manipulations, and Fiona Hollis for technical discussions. Luminescence technical advice was kindly provided by Nathalie Ballanfat and Billy Breton of the EPFL Biomolecular Screening Facility. We would further like to express our gratitude to the anonymous reviewers for their constructive suggestions. This work was supported by grants from the Swiss National Science Foundation (CRSIK0-122691 and 31003AB-135710;
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Programming effects of peripubertal stress on spatial learning
2020, Neurobiology of StressCitation Excerpt :Exposure to adversity during early life can have profound influences on brain function, behavior and cognition at adulthood (Albrecht et al., 2017; Bolton et al., 2017; Sterlemann et al., 2010; Suri et al., 2013), and the precise developmental timing when stress occurs seems to be critical in determining the precise consequences (Gee and Casey, 2015; Lupien et al., 2009). In addition to the recognized impact of neonatal (Bonapersona et al., 2019; Heim and Nemeroff, 2001; Molet et al., 2014; Veenema, 2009) and childhood/juvenile (Albrecht et al., 2017) stress, the peripubertal period is emerging as a time-window of high vulnerability to the programming of emotional (Cordero et al., 2012; Latsko et al., 2016; Márquez et al., 2013; Sheth et al., 2017) and social (Márquez et al., 2013; Poirier et al., 2014; Tzanoulinou et al., 2014a, 2014b) effects of stress (for a review, see (Tzanoulinou and Sandi, 2017). However, despite the well-known modulatory power of stress on cognition (Lupien et al., 2009; Sandi, 2013), little is known about the impact of peripubertal stress on later life cognitive functioning.
Disrupting the endocannabinoid system in early adolescence negatively impacts sociability
2020, Pharmacology Biochemistry and BehaviorCitation Excerpt :A digital camera (SONY HDR-2500) was mounted above each apparatus to record subjects' trials. The three-chambered apparatus has been cited as a valid and reliable apparatus for measuring sociability in both mice and rats (Crawley, 2004; Kaidanovich-Beilin et al., 2011; Nadler et al., 2004; Poirier et al., 2014; Stefanik et al., 2015; Yang et al., 2011; Zhang et al., 2015). Subjects typically express normal sociability by: 1) making more entries into the social chamber (the one that contains a same-sex, conspecific target) vs. an empty chamber, and 2) spending more time investigating the social target vs. an empty cage.
Preclinical models of conduct disorder – principles and pharmacologic perspectives
2018, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Analogous behavioral deficits were readily observed in models of abnormal aggression. Particularly, social deficits were observed in terms of increased social avoidance, as well as impairments is sociability, social recognition, social integration, and sexual behavior (anabolic-androgenic steroids: Salas-Ramirez et al., 2010; early social subjugation: Bastida et al., 2014; glucocorticoid deficiency: File et al., 1979; maternal separation: Toth and Neumann, 2013; peripubertal stress: Poirier et al., 2014; MAOA-KO: Bortolato et al., 2011; post-weaning social isolation: Tulogdi et al., 2014). In addition, cognitive deficits analogous with “impairment in academic functioning” were also observed; these included impaired attention, as well deficits in learning and memory retrieval (anabolic-androgenic steroids: Wallin and Wood, 2015; early subjugation: Novick et al., 2013; Rodriguez-Arias et al., 2014; glucocorticoid deficit: Luine, 1994; maternal separation: Weinstock, 2008; peripubertal stress: Tzanoulinou et al., 2015).
An energetic view of stress: Focus on mitochondria
2018, Frontiers in NeuroendocrinologyCitation Excerpt :For example, treatment with a ketogenic diet – a high-fat low-carbohydrate diet that enhances mitochondrial function – was able to ameliorate impaired mitochondrial respiration and deficits in social behaviors in a valproic acid model of autism in rats (Ahn et al., 2014). In another study, acute infusion in rodents of resveratrol, a compound that activates AMPK-induced mitochondrial biogenesis, counteracted diminished sociability induced by peripubertal stress (Poirier et al., 2014). Similarly, treatment with the antioxidant N-acetyl cysteine reversed impairment in social isolation and accumulated striatal ATP levels observed in a rat model of social isolation rearing stress in rats (Moller et al., 2013).
Emergence in extinction of enhanced and persistent responding to ambiguous aversive cues is associated with high MAOA activity in the prelimbic cortex
2016, Neurobiology of StressCitation Excerpt :Thirty minutes after the end of the fear incubation test session, the subjects were sacrificed, brains were extracted and frozen in isopentane on dry ice for storage at −80 °C until further processing. In order to evaluate regional monoamine oxidase A activity, using a previously published protocol (Poirier et al., 2014), tissue from separate regions was obtained by selectively punching samples of prelimbic (PL), infralimbic (IL), septal (dorsal) hippocampal, temporal (ventral) hippocampal, central amygdala (CeA), and basolateral amygdala (BLA; Harris Uni-Core, Ted Pella, Redding, California, US) from 50 to 200 μm slices obtained on a cryostat (Leica CM3050S) covering the extent of each subregion according to atlas landmarks (Paxinos and Watson, 1997). Mitochondrial, cytoplasmic and nuclei-enriched fractions were obtained using a differential centrifugation protocol.
- 1
Now at Center for Comparative NeuroImaging, Department of Psychiatry, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
- 2
Now at Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan.