Original ArticlesThe Benefits of Early Oral Nutrition in Mild Acute Pancreatitis
Section snippets
Methods
We performed a prospective study (ClinicalTrials.gov: NCT01423786) of patient-directed dietary management of mild acute pancreatitis at Nationwide Children's Hospital in Columbus, Ohio. Patients aged 2-21 years hospitalized with an admission diagnosis of primary or secondary acute pancreatitis from August 2011 through October 2013 were included. Written informed consent was obtained from the parents or guardians of the children who served as subjects in the investigation. We used the Revised
Results
A total of 33 children were recruited to participate in the PDN study. Three patients were withdrawn before any study intervention, as they did not meet inclusion criteria; 30 encounters (29 unique patients) were included for statistical analysis. Table I shows the demographics and baseline clinical variables in the PDN group.
For the TTDN comparison cohort, a total of 165 children were found to have a diagnosis of acute pancreatitis. A total of 73 patients were excluded: 19 patients due to a
Discussion
In our prospective intervention study evaluating nutritional therapy of mild acute pancreatitis in children, we found that patient-directed early oral nutrition was safe and decreased the length of hospitalization. Limited evidence in adult studies of mild acute pancreatitis suggests that early oral feedings may be associated with improved outcomes.6, 18, 19 Eckerwall et al performed a randomized, prospective study comparing traditional fasting with immediate oral feeding in adult patients with
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Cited by (15)
Pancreatitis
2020, Pediatric Gastrointestinal and Liver Disease, Sixth EditionEarly oral nutrition in patients with acute pancreatitis: risk assessment for children and adolescents
2018, Journal of PediatricsEPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis
2018, PancreatologyCitation Excerpt :In another adult study, they administration of solid food was recommended immediately instead of starting with a liquid diet [79]. A pediatric study that examined the role of nutrition in AP, showed that feeds within 24 h of admission are feasible, safe and not associated with increased pain compared to the group of patients that didn't received feeds [80,81]. If adequate oral feeding is not tolerated or the required energy cannot be achieved by oral feeding within 72 h, enteral tube feeding is recommended. (
Acute pancreatitis in children: Risk factors, management, and outcomes
2023, Current Opinion in PediatricsProgress on enteral nutrition therapy for acute pancreatitis
2023, Chinese Journal of Clinical NutritionAcute Pancreatitis in Children
2023, The Pancreas: an Integrated Textbook of Basic Science, Medicine, and Surgery, Fourth Edition
Supported by the intramural funding, grant 277711, through the Research Institute at Nationwide Children's Hospital, Columbus, Ohio. The authors declare no conflicts of interest.