Original ArticleMaternal Asthma, Preterm Birth, and Risk of Bronchopulmonary Dysplasia
Section snippets
Methods
Our analyses used 2 large California-wide datasets. The first dataset was from the California Office of Statewide Health Planning and Development (OSHPD). The OSHPD administrative database captures all hospital discharge diagnoses associated with each woman, including diagnoses antecedent to the pregnancy. We extracted data from this dataset informative of births in the period 2007-2010 and obtained information on maternal delivery discharge records of 2 009 511 pregnancies and their
Results
To reproduce and compare with results from previous studies and to validate our database, we present in Table II (available at www.jpeds.com) the characteristics of the 2 009 511 singleton live births that provided our initial basis of analysis for those with mothers with asthma (2.4%) and those with mothers without asthma. Compared with mothers without asthma, those with asthma were more likely to be obese, to have private insurance, and to be non-Latina black or non-Latina white, and less
Discussion
We found that women with asthma were at greater odds of delivering preterm infants regardless of whether the preterm birth was spontaneous or medically indicated. Interestingly, women with asthma were at higher odds of delivering preterm infants who subsequently developed BPD if they did not receive antenatal steroids.
Our observed prevalence of maternal asthma (2.4%) is similar to that reported in other studies that used a similar approach as ours.11, 12 In contrast, surveys using direct
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Timing of Maternal Asthma Diagnosis in Relation to Adverse Perinatal Outcomes
2020, Journal of Allergy and Clinical Immunology: In PracticeCitation Excerpt :Although no other studies, to our knowledge, have assessed timing of incident diagnosis in relation to pregnancy onset and the risk of adverse pregnancy outcomes, 3 observational studies assessed whether the strength of the association between pre-existing maternal asthma and prematurity varied with time using a fetuses-at-risk approach.25-27 All studies found that the risk of preterm birth among pregnant women with a history of asthma (diagnosis of asthma before pregnancy, during pregnancy, or at delivery) as compared with those without asthma was highest in the third trimester,25-27 with only 1 study also showing an increased risk before the third trimester.26 In 2 of the large retrospective cohort studies consisting of 223,512 and 284,214 singleton deliveries from women with pregnancies lasting ≥23 weeks, Rejno et al27 and Mendola et al25 observed that the association between history of maternal asthma and preterm birth was only evident in women pregnant >31 and >33 weeks (odds ratio [OR] ranging from 1.10 to 1.30), respectively.
Morbidity of Persistent Pulmonary Hypertension of the Newborn in the First Year of Life
2019, Journal of PediatricsCitation Excerpt :Gestational age, birth weight, demographic factors, and maternal diagnoses are also available. The database has been used in multiple studies examining birth and neonatal outcomes.12-18 The study population consisted of live born infants from January 2005 to December 2012.
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The Influence of Asthma and/or Hay Fever on Pregnancy: Data from the 1995 National Survey of Family Growth
2017, Journal of Allergy and Clinical Immunology: In PracticeEpidemiology of Live Born Infants with Nonimmune Hydrops Fetalis—Insights from a Population-Based Dataset
2017, Journal of PediatricsCitation Excerpt :This database includes detailed information on infant characteristics derived from hospital discharge records (neonatal and readmissions) linked to birth and death certificates through 1 year of age. The database has been used in multiple studies examining birth and neonatal outcomes.13-19 GA (best obstetric estimate), birth weight, demographic factors, and maternal diagnoses (from 1 year before birth of the infant) are included.
Supported by March of Dimes Prematurity Research Center at Stanford, CPQCC, Stanford Child Health Research Institute, and the Rosa Wann and Marjorie Shannon Fellowship. The authors declare no conflicts of interest.