Original ArticleEffects of Endotracheal Intubation and Surfactant on a 3-Channel Neonatal Electroencephalogram
Section snippets
Methods
A prospective cohort of 30 infants (24 preterm and 6 full term) who were admitted to the University of California San Diego's Infant Special Care Center and who underwent endotracheal intubation and/or surfactant administration were studied using 3-channel EEG between December 2009 and December 2010. The University's Institutional Review Board approved the study, and previous informed consent was obtained from a parent of each enrolled infant.
Any newborn in the Infant Special Care Center who
Results
The study cohort included 30 patients admitted to the University of California San Diego's Infant Special Care Center between December 2009 and December 2010 (Table). One term infant whose records were not retrievable from the digital recording storage media was excluded from the analysis; thus, 29 infants were analyzed. Birth weight ranged from 590 to 4425 g (mean, 2085 ± 986 g), and gestational age at birth ranged from 25.5 to 41.6 weeks (mean, 33 ± 4.3 weeks). EEG recordings were collected
Discussion
This prospective study found significant brain wave suppression on multichannel EEG after surfactant administration in the majority of infants studied. Our finding of amplitude suppression using multichannel EEG after surfactant administration provides a more detailed look at brain wave suppression than previous studies, which used only single-channel aEEG.4, 5, 6, 7 Brain wave suppression was not correlated with SpO2, BP, heart rate, or TcCO2. Interestingly, 14 of the 18 infants demonstrating
References (30)
- et al.
Surfactant replacement therapy
Chest
(2007) - et al.
Nasotracheal intubation in the neonate: physiologic responses and effects of atropine and pancuronium
J Pediatr
(1984) - et al.
Intracranial pressure during intubation and anesthesia in infants
J Pediatr
(1980) - et al.
Surfactant administration acutely affects cerebral and systemic hemodynamics and gas exchange in very low birth weight infants
J Pediatr
(2004) - et al.
Three-channel electroencephalogram montage in neonatal seizure detection and quantification
Pediatr Neurol
(2011) - et al.
Changes in cortical electrical activity during induction of anaesthesia with thiopental/fentanyl and tracheal intubation: a quantitative electroencephalographic analysis
Br J Anaesth
(2004) - et al.
Effects of morphine on the electroencephalograms of neonates: a prospective, observational study
Clin Neurophysiol
(2000) - et al.
Low-voltage aEEG as predictor of intracranial hemorrhage in preterm infants
Pediatr Neurol
(2011) - et al.
Neonatal EEG: a powerful tool in the assessment of brain damage in preterm infants
Brain Dev
(1999) Surfactant replacement therapy for severe neonatal respiratory distress syndrome: an international randomized clinical trial
Pediatrics
(1988)
Core concepts: respiratory distress syndrome
NeoReviews
Cerebroelectrical depression following surfactant treatment in preterm neonates
Pediatrics
Surfactant administration and the cerebral circulation
Biol Neonate
Effect of the “InSurE” procedure on cerebral oxygenation and electrical brain activity of the preterm infant
Arch Dis Child
Changes in EEG, systemic circulation and blood gas parameters following two or six aliquots of porcine surfactant
Acta Paediatr
Cited by (0)
The authors declare no conflicts of interest.