PathologyLip Cancer: A Clinicopathological Study and Treatment Outcomes in a 25-Year Experience
Section snippets
Study Design and Sample
To address the research purpose, the authors designed and implemented a retrospective cohort study (approved by the human studies committee, protocol number 2011-01314). This study followed the guidelines of the Declaration of Helsinki. The study population was comprised of all patients presenting for evaluation and treatment of LSCC from January 1989 through December 2013 at the Oral Oncology Center, Araçatuba Dental School, São Paulo State University (UNESP), Brazil.
Patients were included in
Epidemiologic Features
Clinical reports of 144 patients with LSCC were studied. There were 117 men (81.25%) and 27 women (18.75%) whose age ranged from 19 to 98 years (mean, 60.21 yr). The age intervals of younger than 53 years (32.00%), 53 to 65 years (29.80%), 66 to 75 years (17.36%), and older than 75 years (20.84%) were considered for this study, according to age range lip cancer criteria defined by Czerninski et al.5 Analysis of gender with age range showed no statistical differences (P = .0967). One hundred
Discussion
The purpose of this study was to investigate the clinicopathologic profile and treatment outcomes of patients with LSCC treated in a single institution for the past 25 years. Based on the literature and the authors' clinical experience, the study's main hypothesis predicted that clinicopathologic variables would affect treatment outcomes in patients with LSCC. In this retrospective cohort study, most patients with LSCC were men (81.25%), had white ethnicity (93.05%), had the tumor located in
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Lip and Oral Cavity Squamous Cell Carcinoma
2021, Hematology/Oncology Clinics of North AmericaHistory and future perspectives for the use of fluorescence visualization to detect oral squamous cell carcinoma and oral potentially malignant disorders
2019, Photodiagnosis and Photodynamic TherapyCitation Excerpt :Although tobacco smoking is the major risk factor for OSCC, the association with alcohol drinking increases the risk of OSCC up to 100-fold [8–10]. Other risk factors have been associated with the occurrence of oral cancer, like the development of SCC in lip vermilion due to chronic and unprotected exposure to solar radiation [11,12]; and human papillomavirus (HPV) infection, which has been associated with the occurrence of OSCC in some groups [13–16]. Since the factors capable of trigger the oral mucosal carcinogenesis are known, we can define groups of people at high-risk for OSCC [17].
Participation of hypoxia-inducible factor-1α and lymphangiogenesis in metastatic and non-metastatic lower lip squamous cell carcinoma
2018, Journal of Cranio-Maxillofacial SurgeryOld Age Lower Lip Cancer Defects Reconstruction by Abbe-Estlander Flap
2018, International Journal of GerontologyCitation Excerpt :Lip squamous cell carcinoma (SCC) is one of the major causes of defect which needs to be reconstructed. It accounts for 12–30% of oral cavity cancer and raises the proportion of incidence in old age population.2–4 Most lip cancers are located on lower lips which associates with high level exposure of ultraviolet radiation.4
Surgical Management of Oral Cancer
2018, Dental Clinics of North AmericaCitation Excerpt :Furthermore, the presence of a close (1–5 mm) margin has been demonstrated in several studies in decreasing overall survival and disease-free survival; therefore, additional adjuvant XRT is recommended.6 Of the oral cavity subsites, lip cancers, in general, have the most favorable prognosis.9 Lip cancer margins are the most conservative of all the oral cavity subsites, which are 0.5 to 1 cm (5–10 mm).
Intraoral stents in preventing adverse radiotherapeutic effects in lip cancer patients
2017, Reports of Practical Oncology and RadiotherapyCitation Excerpt :The worldwide available data reveal that this type of cancer occurs mostly in white men (with a male-to-female ratio of 28.5:4.3), with peak incidence in the sixth and seventh decades, and among people working under conditions of prolonged sun exposure, such as agricultural workers and those with other outdoor occupations.1,2,4 The etiology of lower lip SCC is highly related to chronic sunlight (especially UVB) exposure and other factors, such as low sociodemographic conditions, genetic susceptibility, and immunosuppression, which might produce a synergistic effect.2,4,5 However, the definitive pathogenic pathway remains unclear.
Conflict of Interest Disclosures: None of the authors have any relevant financial relationship(s) with a commercial interest.