PathologyAmeloblastoma of the Jaws: A Retrospective Analysis of 340 Cases in a Malaysian Population
Section snippets
Materials and Methods
The surgical biopsy records of all histologically diagnosed cases of ameloblastoma archived from January 1993 through December 2008 inclusive were retrieved from the files of the Unit of Stomatology, Institute for Medical Research and the Department of Oral Pathology, Oral Medicine, and Periodontology, Faculty of Dentistry, University of Malaya, Kuala Lumpur, Malaysia. This was a retrospective study that was exempted from institutional review board approval (research grant RG83/09HTM). A
Clinical Findings
From the 1,234 cases of odontogenic tumors (excluding keratocystic odontogenic tumors) accessioned over the 16-year study period, 340 histologically confirmed ameloblastomas were analyzed, yielding an incidence of 27.6%. The distribution of these cases according to ethnicity, anatomic location, mean duration, radiologic appearance, and clinicopathologic subtypes are presented in Table 1. Statistical analysis showed significant differences in the distribution of ameloblastoma in relation to
Discussion
In the present study, all 340 cases were classified according to the new 2005 WHO classification.1 A search of the English-language literature disclosed few reports that reviewed large series of ameloblastomas per se9, 10, 11, 12 or odontogenic tumors13, 14, 15, 16 in accordance with the new 2005 WHO classification.1 Recent ameloblastoma review series have included a multicentric Latin-American study on 163 cases of ameloblastoma,9 a critical appraisal of 25 cases from a single institution,10 a
Acknowledgments
The authors thank all clinical specialists at the Ministry of Health, Malaysia, Faculty of Dentistry, University of Malaya and private hospitals/clinics for their case contributions that made this project possible. This study was supported by a grant from the University of Malaya (RG083/09HTM).
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