CONSORT Randomized Clinical TrialPostoperative Pain after Endodontic Treatment under Irrigation with 8.25% Sodium Hypochlorite and Other Solutions: A Randomized Clinical Trial
Section snippets
Materials and Methods
This double-blind randomized controlled trial was approved by the Institutional Research Ethics Committee under registration no. 2,406,004 and registered in the Brazilian Registry of Clinical Trials (Registro Brasileiro de Ensaios Clínico, http://www.ensaiosclinicos.gov.br/, database no. RBR-33yhw9).
The sample calculation for the research was based on a pilot study in which patients who used 2% CHX constituted a control group, which had a lower percentage of patients who had pain; the 5.25%
Results
The flowchart of the study is presented in Figure 1. The patients’ return rate was 93.9% (n = 169) with groups and those who respectively remained (2% CHX and 2.5% NaOCl, n = 43; 5.25%, n = 42; and 8.25%, n = 41). Dropouts simply did not return to the follow-up, without there being any specific reason for that.
The results of the descriptive analysis of demographic and clinical characteristics for each group are shown in Table 1. Of the 169 participants, 107 (63.3%) were women, and 62 (36.7%)
Discussion
This study attempted to evaluate endodontic postoperative pain at different time points in patients undergoing treatment with different irrigation solutions. No significant difference between the irrigants occurred, but 5.25% NaOCl showed the highest percentage of postoperative pain (28.6%) followed by 8.25% NaOCl (24.4%), whereas 2.5% NaOCl and 2% CHX were represented by 14% of the cases. Other variables, such as extended preparation time and overfilling, were associated with pain outcomes.
The
Conclusion
The 8.25% NaOCl solution was not significantly more associated with either the presence or intensity of pain compared with other solutions. An extended preparation time and overfilled material have a negative impact on the incidence of postoperative pain, which is more frequently reported in the first 24 hours. Thus, 8.25% NaOCl can be used as an irrigant solution as long as the preparation time is reduced.
Acknowledgments
The authors deny any conflicts of interest related to this study.
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2022, Photodiagnosis and Photodynamic TherapyCitation Excerpt :The higher cytotoxicity of hypochlorite concentration irrigating solution can be explained by its chemical properties of dissolving organic tissues and its toxicity, by recruiting an expressive number of inflammatory mediators [5]. The organic tissue dissolving properties and cytotoxicity effect of sodium hypochlorite are proportional to the irrigating solution concentration [28,29], justifying the results obtained in the present study. In the same way, it is crucial to assess the potentially toxic effects of photodynamic therapy to the host´s cells, which are also affected by the singlet oxygen action [30].
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2022, Journal of EndodonticsCitation Excerpt :In this regard, the microbiota of teeth with irreversible pulpitis may have similarities with persistent/secondary endodontic infections due to the levels of LPS and LTA11,19. The use of NaOCl at higher concentrations was proposed because it improves pulp tissue dissolution38 without interfering with postoperative pain compared with other concentrations of NaOCl and chlorhexidine39. This was a pioneer investigation conducted to monitor the levels of bacteria, LPS, and LTA in teeth with symptomatic irreversible pulpitis in different phases of endodontic treatment performed with 6% NaOCl.
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