Clinical ResearchRegenerative Potential of Immature Permanent Teeth with Necrotic Pulps after Different Regenerative Protocols
Section snippets
Materials and Methods
Thirty-six patients with immature, nonvital maxillary anterior teeth presenting with or without signs and/or symptoms of periapical pathology were included in this study from the outpatient clinic of the Faculty of Dentistry, Ain Shams University, Cairo, Egypt. A detailed medical and dental history was obtained from each patient's parents or guardians. Only medically free patients were included in this research. The clinical and radiographic exclusion criteria were teeth with vertical
Results
Patients' demographic data are summarized in Table 1. A total of 7 patients were excluded from the study because of inadequate compliance and failure to recall. Three cases were excluded from the MTA group, 2 cases were excluded from the REG group, and 2 cases were excluded from the FGF group. The percentages of recall for the MTA, REG, and FGF groups were 75%, 83%, and 83% respectively. Clinical and radiographic examination during the follow-up period showed signs and symptoms of failure in 3
Discussion
The management of immature necrotic teeth has been considered a great challenge in endodontics. Historically, the treatment of such cases was performed using calcium hydroxide apexification. However, the long-term use of calcium hydroxide has several drawbacks (21), including multiple patient visits, low patient compliance, probability of canal contamination between visits, and increased dentin brittleness, which increase the risk of fracture (21).
The technique of an immediate apical plug has
Conclusions
Under the circumstances of this study, it can be concluded that both treatment protocols (ie, an MTA apical plug and the regenerative endodontic procedure) were successful treatment options with regard to the closure of open apices. Regenerative endodontic procedures induced an increase in root length, thickness, and apical closure. The use of an artificial hydrogel scaffold and bFGF was not essential for repair.
Acknowledgments
The authors thank Professor Yasuhiko Tabata for providing the hydrogel gel scaffold and bFGF used in this study.
The authors deny any conflict of interest related to this study.
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