Labeling of macrophages using bacterial magnetosomes and their characterization by magnetic resonance imaging

doi:10.1016/j.jmmm.2006.10.1153

Journal of Magnetism and Magnetic Materials

Volume 311, Issue 1, April 2007, Pages 454-459

https://doi.org/10.1016/j.jmmm.2006.10.1153 Get rights and content

Abstract

This work investigated macrophages labeled with magnetosomes for the possible detection of inflammations by MR molecular imaging. Pure magnetosomes and macrophages containing magnetosomes were analyzed using a clinical 1.5 T MR-scanner. Relaxivities of magnetosomes and relaxation rates of cells containing magnetosomes were determined. Peritonitis was induced in two mice. T₁, T₂ and T₂* weighted images were acquired following injection of the probes. Pure magnetosomes and labeled cells showed slight effects on T₁, but strong effects on T₂ and T₂* images. Labeled macrophages were located with magnetic resonance imaging (MRI) in the colon area, thus demonstrating the feasibility of the proposed approach.

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Labeling of macrophages using bacterial magnetosomes and their characterization by magnetic resonance imaging

Abstract

Ann. Biomed. Eng.

Nature

J. Leukoc. Biol.

Invest. Radiol.

Radiology

Röfo

Radiology