Letter to the EditorDetection of Fusarium-specific T cells in hematologic patients with invasive fusariosis
Section snippets
Author contributions
Conceived and designed the experiments: DV, FF, PBa, GR, ML and LP. Performed the experiments: DV, IL, GR and CQ. Analyzed the data: DV, FF, IL, GR and PBa. Wrote the paper: DV, FF, GR, PBa and LP. Provided well-characterized patient samples and related data: FF, MMo, PBr, AC, VC, MMa, AP, EC, RM, FN, MC, LI, PC, DC and TT. Critically revised the manuscript: MMo, PBr, AC, VC, MMa, AP, EC, RM, FN, AB, JPL, LR, MC, LI, PC, DC, TT, and ML.
Conflicts of interest
M. Luppi serves in Advisory Boards for Merck Sharp & Dohme and Gilead Sciences, and received honoraria from these two pharmaceutical industries and from Pfizer and Nanogen. L. Potenza serves in an Advisory Board for Merck Sharp & Dohme and received grant support from Pfeizer. M. Luppi, L. Potenza and P. Barozzi have applied for an Italian patent regarding clinical applications of the ELISpot assay for the diagnosis of Aspergillus infection [PCT: WO2008/075395A3, IT2007/000867]. M. Luppi, L.
Acknowledgments
The authors would like to thank, for the supporting by grants, the Ministero della Salute (Ricerca Finalizzata, GR-2010-2313609, to L.P. and M.L.), the Associazione Italiana per la Ricerca sul Cancro (AIRC, IG 14797-2013, to M.L.), and the Associazione Italiana Lotta alle Leucemie, Linfoma e Mieloma (AIL) – Sezione ‘Luciano Pavarotti’ Modena-ONLUS. The work was part of a scientific cooperation between IRCCS Pavia and AOU Policlinico Modena and a counseling scientific program of P.C. at
References (10)
- et al.
Phylogenetic diversity of human pathogenic Fusarium and emergence of uncommon virulent species
J Infect
(2015 Dec) - et al.
Mucorales-specific T cells emerge in the course of invasive mucormycosis and may be used as a surrogate diagnostic marker in high-risk patients
Blood
(2011) - et al.
Fusarium infections in immunocompromised patients
Clin Microbiol Rev
(2007) - et al.
Earlier diagnosis of invasive fusariosis with Aspergillus serum galactomannan testing
PLoS One
(2014 Jan 28) - et al.
Characterization of specific immune responses to different Aspergillus antigens during the course of invasive Aspergillosis in hematologic patients
PLoS One
(2013)
Cited by (5)
Anti-fungal T cell responses in the lung and modulation by the gut-lung axis
2020, Current Opinion in MicrobiologyCitation Excerpt :As outlined above T cells do probably not play a major role in preventing invasive Aspergillosis. Instead, fungus-specific effector T cells are expanded in patients with invasive Aspergillus-infections, Mucorales-infections or Fusarium-infections [21–27], as well as Candida blood-stream infections [28•,29] and even allow sensitive and specific diagnosis [21,23,25,28•,29]. These data further suggest that the massively expanded fungus-specific T cell responses may not contribute to infection resolution, but are shifted towards an anti-inflammatory [22] or dysfunctional (Bacher, Scheffold unpublished), non-protective phenotype, but may regain functionality following resolution of the infection [30].
Results of endoscopic nasal surgery in the treatment of invasive fungal sinusitis in children with cancer and immunosuppression
2019, Acta Otorrinolaringologica EspanolaMethods of controlling invasive fungal infections using CD8<sup>+</sup> T cells
2018, Frontiers in Immunology