Letter to EditorUsing precision dosing to minimize cefepime-induced neurotoxicity: The challenge of targets
Section snippets
Authorship statement
All authors met the ICMJE authorship criteria.
Funding
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.
Declaration of competing interest
None.
Acknowledgments
None.
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Cited by (5)
Assessment of cefepime toxicodynamics: comprehensive examination of pharmacokinetic/pharmacodynamic targets for cefepime-induced neurotoxicity and evaluation of current dosing guidelines
2021, International Journal of Antimicrobial AgentsCitation Excerpt :One study used patient simulations to propose that cefepime plasma maximum serum concentration (Cmax) and steady-state daily area under the concentration–time curve (AUC24) may be better predictors of the development of CIN than trough concentrations [17]. In addition, there has been a call for further work to ‘better define the safe therapeutic range for cefepime’ by investigating alternative pharmacokinetic parameters which may better correlate with CIN [18], given that most of the previous studies determining the cefepime toxicodynamic threshold only investigated Cmin [13–16]. Therefore, the primary objective of this study was to identify the optimal cefepime threshold for CIN.
Cefepime Precision Dosing Tool: From Standard to Precise Dose Using Nonparametric Population Pharmacokinetics
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