Letter to the EditorReply to: “Lack of Kupffer cell depletion in diethylnitrosamine-induced hepatic inflammation”
Section snippets
“Stay here or disappear”: Kupffer cell behaviour during liver injury
Kupffer cells (KC) are liver-resident macrophages that during homeostasis display an overall anti-inflammatory phenotype.1 Upon infection, KCs critically shape the local inflammatory immune milieu, either by supporting inflammation and controlling the infection, or by maintaining tolerance.2 Liver injury mostly results from infection or intoxication and is typically accompanied by local inflammatory reactions of varying quality and quantity. Recent studies demonstrated fulminant KC loss during
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The authors declare no conflicts of interest that pertain to this work.
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Cited by (4)
Liver macrophages in health and disease
2022, ImmunityCitation Excerpt :Moreover, some studies have only assessed KC proportions and not absolute numbers. Thus, whether liver disease always leads to a true reduction in bona fide resident KCs remains contentious (Alazawi and Knolle, 2018; Borst et al., 2019a, 2019b; Kessler et al., 2019; Lefere et al., 2019). Further investigation into this is, therefore, needed across diseases utilizing multiple lines of investigation, whereby KC numbers can be accurately assessed.
Sex Drives Functional Changes in the Progression and Regression of Liver Fibrosis
2023, International Journal of Molecular Sciences
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Authors contributed equally.