Case reportAdenomyomatous polyp of the uterus: Report of an autopsy case and review of the literature
Introduction
Adenomyomatous polyp (polypoid adenomyoma) of the endometrium is a subtype of endometrial polyp consisting of smooth muscle, endometrial glands, and often scant endometrial stroma.1, 2 The few reports in the literature describe these as lesions grossly indistinguishable from ordinary endometrial polyps occurring in the fourth decade or later.1, 2, 3, 4, 5, 6, 7, 8 We report a case of an adenomyomatous polyp of the endometrium in a young nulliparous woman which was incidentally identified at a medicolegal autopsy. To our knowledge, this is the first case reported in a woman younger than the fourth decade as well as the first to be reported in the forensic setting. Furthermore, it is the third case reported with no association to tamoxifen therapy.
Section snippets
Case report
A 23-year-old woman was involved in a traffic accident in South India and died instantaneously. Her past medical history was relatively innocuous; there was no history of hormonal intervention via contraceptives or tamoxifen use. No history of dysfunctional uterine bleeding was obtained. The patient was nulliparous and had menstrual periods monthly since the age of 14.
Medicolegal investigation and autopsy were performed following the accident. Grossly the uterus, fallopian tubes, and ovaries
Discussion
Endometrial polyps of the adenomyomatous type are rare.2, 8 Five cases have been reported to date, the details of which are presented in Table 1. Endometrial polyps are sessile masses, single or multiple of variable size ranging from 0.5 to 3 cm in diameter but occasionally large and pedunculated projecting into the endometrial cavity.3 These polyps originate as focal hyperplasias of the basalis which develop into benign, localized overgrowths of endometrial tissue covered by epithelium and
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Cited by (12)
Clinicopathological and immunohistochemical features of uterine adenomyomatous polyps
2019, Human PathologyCitation Excerpt :The relationship between APs and infertility and hormonal therapy is also a subject of debate [4,5]. APs have a diverse histology, according to case reports [6-8], and can appear similar to more worrisome entities, including atypical polypoid adenomyoma and adenosarcoma [3,9]. If APs represent superficial smooth muscle neoplasms, it is possible that they harbor mutations in the MED12 (mediator complex subunit 12) gene, which is reportedly altered in up to 70% of uterine leiomyomas [10], or gene rearrangements involving HMGA2 (high mobility group AT-hook 2) [11].
The typical polypoid adenomyoma is a special form of endometrial polyp: a case-controlled study with a large sample size
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