Elsevier

Journal of Functional Foods

Volume 84, September 2021, 104575
Journal of Functional Foods

Mulberry (Morus atropurpurea Roxb.) leaf protein hydrolysates ameliorate dextran sodium sulfate-induced colitis via integrated modulation of gut microbiota and immunity

https://doi.org/10.1016/j.jff.2021.104575Get rights and content
Under a Creative Commons license
open access

Highlights

  • Mulberry leaf protein hydrolysates (MLPH) efficiently alleviated DSS-induced colitis.

  • Prevention and therapeutic intervention was more effective than therapeutic intervention.

  • MLPH reversed microbiota dysbiosis and increased colonization of SCFA-producing genera.

  • Lactobacillus and Desulfovibrio are the key bacteria in MLPH group.

  • Dominant genera in MLPH group positively correlated with IBD prevention parameters.

Abstract

The molecular action underlying peptide intervention before and after colitis induction is different. To investigate the alleviated effects of mulberry leaf protein hydrolysates (MLPH) on colitis and its potential mechanism, MLPH was administered to colitis mice. Results showed that MLPH efficiently alleviated the colitis, and the preventive and therapeutic (P&T) intervention was more effective than the therapeutic intervention alone. MLPH significantly decreased pro-inflammatory cytokines, improved histological damage, and increased SCFA contents. MLPH also reversed microbiota dysbiosis. The dominant genera in MLPH intervention group were significantly positively correlated with colitis prevention parameters (p < 0.01). The DSS group was the opposite. In addition, the dominant genera of MLPH intervention group showed a co-occurrence relationship with each other. Overall, MLPH could alleviate colitis by integrated modulation of gut microbiota and inflammation response. MLPH may be a promising dietary approach for sustaining gut health to lower the risk of developing colitis.

Keywords

Mulberry leaf protein hydrolysates
Colitis
DSS
Gut microbiota
Correlation analysis
Key bacteria

Cited by (0)

1

Chongzhen Sun, Xin Tang and Xin Shao contributed equally to work study and share first authorship.