Effects of long-term feeding diets supplemented with Lactobacillus reuteri 1 on growth performance, digestive and absorptive function of the small intestine in pigs

https://doi.org/10.1016/j.jff.2020.104010Get rights and content
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Highlights

  • LR1 promoted pig growth.

  • LR1 improved intestinal hormone, digestion and absorption.

Abstract

This study aimed to investigate the effects of long-term feeding diets supplemented with antibiotics and Lactobacillus reuteri 1 (LR1) on growth performance, intestinal digestion and absorption in pigs. The results showed that both LR1 and the antibiotics increased body weight of the piglets after 42-d (P < 0.05), and showed a tendency to promote growth performance in growing-finishing pigs. LR1 significantly improved jejunal and ileal mucosal morphology and increased expression of jejunal glucosidase and ileal cholecystokinin, digestive enzymes and nutrient transporters. The antibiotics decreased jejunal lactase, B0 + AT1, FATP1, GLUT2, ileal y + LAT1, and GLUT2 (P < 0.05). LR1 stimulated protein synthesis of ileal mucosa rather than jejunal mucosa compared to control and antibiotic groups (P < 0.05). In conclusion, LR1 could be an alternative to antibiotics as a growth promoter that improves mucosal morphology, synthesis and secretion of cholecystokinin and digestion and absorption of small intestine.

Keywords

Lactobacillus reuteri 1
Growth performance
Intestinal digestion and absorption
Pigs

Abbreviations

ADG
average daily gain
ADFI
average daily feed intake
F/G
he feed to gain ratio
EAAT3
Glutamate and aspartate transporter
4F2hc
4F2 cell-surface antigen heavy chain
ASTC2
Alanine serine cysteine threonine transporters
B0+AT
Glycoprotein-associated amino acid transporter
PAT1
proton-coupled amino acid transporter 1
PepT1
Peptide transporter
SNAT2
Sodium-coupled neutral amino acid transporter 2
Y+LAT1
y+L amino acid transporter-1
CAT1
Cationic AA transporters
APOA1
Apolipoprotein A1
FADS
fatty acid desaturase
FATP1
Fatty acid transport protein 1
SGLT-1
Sodium-glucose co-transporter-1
GLUT2
Glucose transporter 2
mTOR1
Mammalian target of rapamycin
TSC2
Tuberous sclerosis complex 2
S6K1
S6 kinase 1
4E-BP1
Initiation factor 4E binding protein

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