Nano-targeted relaxin impairs fibrosis and tumor growth in pancreatic cancer and improves the efficacy of gemcitabine in vivo
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Graphical abstract
Keywords
Relaxin-2
Superparamagnetic iron-oxide nanoparticles
Pancreatic stellate cells
Cancer-associated fibroblasts
Pancreatic cancer
Tumor stroma
Abbreviations
hPSCs
human pancreatic stellate cells
CAFs
cancer-associated fibroblasts
PDAC
pancreatic ductal adenocarcinoma
RLX
Relaxin-2
SPION
superparamagnetic iron oxide nanoparticles
Gem
gemcitabine
TGF-β
transforming growth factor β
ECM
extracellular matrix
α-SMA
α-smooth muscle actin
Col-I
collagen-I
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These authors contributed equally to this work.
© 2018 The Authors. Published by Elsevier B.V.