Original ResearchExperimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)
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Author contributions David J. Harrison, acquired, analyzed, and interpreted pathology data; obtained funding; drafting of the manuscript. Dorothy Kisielewski, study design, acquired data. Diane M. Cassidy, acquired data. Alison D. McNeilly, acquired data. Jennifer R. Gallagher, acquired data. Shaun V. Walsh, acquired data. Tadashi Honda, synthesized TBE-31 and obtained funding. Rory J. McCrimmon, obtained funding, supervised staff. Albena T. Dinkova-Kostova, obtained funding, supervised staff, drafting of the manuscript. Michael L. J. Ashford, study concept and design, obtained funding, drafting of manuscript. John F. Dillon, study concept and design, supervised staff, obtained funding, corrected drafts of manuscript. John D. Hayes, study concept and design, interpreted data, supervised staff, obtained funding, wrote all drafts of manuscript and approved final text.
Conflicts of interest The authors disclose no conflicts.
Funding Supported by grants MR/J001465/1 (JDH, MLJA, JFD, and RJMcC) and MR/N009851/1 (JDH, MLJA, ATD-K, and DJH) from the Medical Research Council of the United Kingdom and grants from Stony Brook Foundation and Reata Pharmaceuticals, Inc (TH).