Cellular and Molecular Gastroenterology and Hepatology
Volume 2, Issue 6, November 2016, Pages 796-810
Original ResearchHypoxia Positively Regulates the Expression of pH-Sensing G-Protein–Coupled Receptor OGR1 (GPR68)
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open access
Keywords
Ovarian Cancer G-Protein–Coupled Receptor
Inflammation
Inflammatory Bowel Disease
TDAG8
GRP65
Abbreviations used in this paper
AICAR
5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside
CD
Crohn's disease
ChIP
chromatin immunoprecipitation
FCS
fetal calf serum
GPR
G-protein–coupled receptor
HIF
hypoxia-inducible factor
HV
healthy volunteer
IBD
inflammatory bowel disease
IEC
intestinal epithelial cell
IFN
interferon
IL
interleukin
MM6
MonoMac 6
mRNA
messenger RNA
NF-κB
nuclear factor-κB
OGR1
ovarian cancer G-protein–coupled receptor 1 (GPR68)
RT-qPCR
quantitative reverse-transcription polymerase chain reaction
SPARC
secreted protein acidic and rich in cysteine
TDAG8
T-cell death-associated gene 8 (GPR65)
Th
T-helper
TNF
tumor necrosis factor
UC
ulcerative colitis
WT
wild type
Cited by (0)
Conflicts of interest The authors disclose no conflicts.
Funding This research was supported by the University of Zurich Center for Integrative Human Physiology (C.A.W. and G.R.), grants from the Swiss National Science Foundation (310030-120312 to G.R. and 31003A_155959/1 to C.A.W.), and the Swiss Inflammatory Bowel Disease Cohort (3347CO-108792). Also supported by the European Crohn's and Colitis Organisation Fellowship (J.C.-R.).
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Authors share co-first authorship.
© 2016 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.