Percutaneous Left Atrial Appendage Closure With the LAmbre Device for Stroke Prevention in Atrial Fibrillation: A Prospective, Multicenter Clinical Study

doi:10.1016/j.jcin.2017.06.072

JACC: Cardiovascular Interventions

Volume 10, Issue 21, 13 November 2017, Pages 2188-2194

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Abstract

Objectives

The authors sought to assess the clinical outcomes of left atrial appendage (LAA) closure with the LAmbre closure system in patients with nonvalvular atrial fibrillation (NVAF).

Background

Over 90% of thrombi are located in the LAA in NVAF patients.

Methods

A prospective, multicenter study was conducted in 153 NVAF patients with CHADS₂ score ≥1.

Results

The LAA was successfully occluded in 152 patients. Serious complications occurred in 5 patients. During the 12-month follow-up, ischemic stroke occurred in 2 patients, 1 patient had incomplete LAA sealing, and there was no device embolization.

Conclusions

LAA closure with the LAmbre device shows encouraging results for stroke prevention.

Graphical abstract

Key Words

atrial fibrillation

LAmbre

left atrial appendage closure

stroke

Abbreviations and Acronyms

atrial fibrillation

CHADS₂

congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, and prior stroke or transient ischemic attack

CHA₂DS₂-VASc

congestive heart failure, hypertension, age ≥75 years (doubled), diabetes mellitus prior stroke or transient ischemic attack (doubled). vascular disease, age 65 to 74 years, and sex category (female)

LAA

left atrial appendage

NVAF

nonvalvular atrial fibrillation

TEE

transesophageal echocardiography

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: This work was supported by grants from the National Natural Science Foundation of China (No. 81570306 and No. 81570459), and the Science and Technology Support Program of Hubei Province (No. 2013BCB013). The authors have reported that they have no relationships relevant to the contents of this paper to disclose. The first two authors contributed equally to this work.