Journal of Biological Chemistry
Volume 298, Issue 4, April 2022, 101804
Research ArticleProtein tyrosine kinase Abl promotes hepatitis C virus particle assembly via interaction with viral substrate activator NS5A
Under a Creative Commons license
open access
Keywords
protein tyrosine kinase
phosphotyrosine
host factors against virus infection
assembly of infectious virus particle
Abl tyrosine kinase
hepatitis C virus
viral protein
nonstructural protein 5A
Abbreviations
Abl
Abelson
Abl−
Abl-deficient cell
AFK
Abl family kinase
cDNA
complementary DNA
DAA
direct-acting antiviral
DOC
sodium deoxycholate
DSL
detergent-soluble lysate
edR
editing-resistant
ER
endoplasmic reticulum
HCV
hepatitis C virus
HCVcc
cell culture–adapted HCV
HEK 293T
human embryonic kidney 293T cell line
IgG1
immunoglobulin G1
KD
kinase-dead
mAb
monoclonal antibody
NS5A
nonstructural protein 5A
pTyr
phosphotyrosine
SH3
Src homology 3
TCID50
median tissue culture infectious dose
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Published by Elsevier Inc on behalf of American Society for Biochemistry and Molecular Biology.