Journal of Biological Chemistry
Volume 296, January–June 2021, 100526
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Editors' Pick Highlight
Plasmodium falciparum finds the winning combination

https://doi.org/10.1016/j.jbc.2021.100526Get rights and content
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After 3 years of laboratory drug pressure in the presence of a picomolar inhibitor, the parasite Plasmodium falciparum developed a combination strategy of gene amplification and mutation to regain viability. The mutation observed led to a dysfunctional enzyme, but new research reveals the clever mechanism behind its success. Not that we needed a reminder of nature’s creativity in the time of a pandemic.

Keywords

drug resistance mechanism
hybrid protein
DADE-ImmG
Plasmodium falciparum
malaria

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