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This study was supported by AstraZeneca.

Conflicts of interest: H. K. Reddel reports personal fees and nonfinancial support from AstraZeneca during the conduct of the study; grants, personal fees, and nonfinancial support from AstraZeneca outside of the presented work; grants, personal fees, and nonfinancial support from GlaxoSmithKline; grant and personal fees from Novartis; and personal fees from Sanofi-Genzyme, Merck, Boehringer Ingelheim, Chiesi, Mundipharma and Teva outside of the presented work; and is Chair of the GINA Scientific Committee and a member of the GINA Board. P. M. O'Byrne reports grants and personal fees from AstraZeneca during the conduct of the study; personal fees from GlaxoSmithKline, Chiesi and Menarini; grants to McMaster University from Novartis, MedImmune, Merck, Bayer, and Genentech outside of the presented work. J. M. FitzGerald reports grants and personal fees from AstraZeneca during the conduct of the study; grants to UBC from AstraZeneca, Novartis, Boehringer Ingelheim, GlaxoSmithKline, and sanofi-aventis outside the presented work; personal fees from GlaxoSmithKline, Novartis, Sanofi Regeneron, and Boehringer Ingelheim; and is a Member of the GINA Board and Science Committee. P. J. Barnes reports grants and personal fees from AstraZeneca, during the conduct of the study. J. Zheng reports personal fees from AstraZeneca and Boehringer Ingelheim. S. Ivanov, R. Lamarca, M. Puu, and V. K. T. Alagappan are employees of AstraZeneca. E. D. Bateman reports personal fees from AstraZeneca, ALK, Boehringer Ingelheim, Menarini, Novartis, Orion, Regeneron, and Sanofi; and is a member of the Board and Science Committee of GINA.

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