Letter to the EditorThe parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma
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Cited by (11)
Mining Helminths for Novel Therapeutics
2021, Trends in Molecular MedicineCitation Excerpt :Suppression of this type 2 immune response was beneficial in decreasing airway inflammation in a murine asthma model [88] (Figure 2). Similar to FhHDM-1, F. hepatica total extract (FHTE) also attenuated autoimmune encephalomyelitis in a murine model by interfering with IL-1β and IL-23 activation of γδT and Th17 cells [88,89]. During type 2 immune responses, B cells undergo class-switching resulting in IgE and IgG production.
Potential Influence of Helminth Molecules on COVID-19 Pathology
2021, Trends in ParasitologyFasciola hepatica-derived molecules as potential immunomodulators
2020, Acta TropicaCitation Excerpt :In both cases, T1D and EAE, this protein increased the survival rate and reduced the percent of NOD mice with insulitis or clinical symptoms, inflammation, and demyelination in Central Nervous System respectively (Lund et al., 2016). Besides, Tanaka et al. showed that, in an asthma model, this protein reduced the numbers of neutrophils, lymphocytes, and eosinophils in bronchoalveolar lavage fluid as well as the inflammation and mucus production in the lung (Tanaka et al., 2018). Finally, in a murine model of rheumatoid arthritis induced by collagen type II, Khan et al. evidenced that this F. hepatica-derived molecule protects against cartilage loss and the architecture destruction.
Advances in asthma in 2017: Mechanisms, biologics, and genetics
2018, Journal of Allergy and Clinical ImmunologyCitation Excerpt :The products of this response might have a clinical application. Tanaka et al89 examined a peptide secreted by an animal and human parasite, Fasciola hepatica. The peptide Fasciola hepatica helminth defense molecule 1 (FhHDM-1) has potential anti-inflammatory properties.
Research advances of the immune regulation of helminths and their derived molecules on mite⁃induced asthma
2023, Chinese Journal of Parasitology and Parasitic Diseases
A.T. is supported by an Australian Government Research Training Program Scholarship. V.S.R.R.A. is supported by a University of Technology Sydney Postgraduate Research Scholarship. N.T. is supported by the Swiss National Science Foundation (grant P300PA_164715). C.T. and S.W. are supported by the Medical Research Council. J.P.D. is funded by grants from a European Research Council Advanced Grant (HELIVAC, 322725) and is a member of the Horizon 2020-funded Consortium PARAGONE. S.D. is funded by the National Health and Medical Research Council Australia (APP1087341).
Disclosure of potential conflict of interest: S. Donnelly and J. Dalton are both named inventors on a patent application covering the use of FhHDM-1 as an immune-modulating agent. The rest of the authors declare that they have no relevant conflicts of interest.
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These authors contributed equally to this work.