Letter to the Editor
The parasitic 68-mer peptide FhHDM-1 inhibits mixed granulocytic inflammation and airway hyperreactivity in experimental asthma

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Cited by (11)

  • Mining Helminths for Novel Therapeutics

    2021, Trends in Molecular Medicine
    Citation Excerpt :

    Suppression of this type 2 immune response was beneficial in decreasing airway inflammation in a murine asthma model [88] (Figure 2). Similar to FhHDM-1, F. hepatica total extract (FHTE) also attenuated autoimmune encephalomyelitis in a murine model by interfering with IL-1β and IL-23 activation of γδT and Th17 cells [88,89]. During type 2 immune responses, B cells undergo class-switching resulting in IgE and IgG production.

  • Fasciola hepatica-derived molecules as potential immunomodulators

    2020, Acta Tropica
    Citation Excerpt :

    In both cases, T1D and EAE, this protein increased the survival rate and reduced the percent of NOD mice with insulitis or clinical symptoms, inflammation, and demyelination in Central Nervous System respectively (Lund et al., 2016). Besides, Tanaka et al. showed that, in an asthma model, this protein reduced the numbers of neutrophils, lymphocytes, and eosinophils in bronchoalveolar lavage fluid as well as the inflammation and mucus production in the lung (Tanaka et al., 2018). Finally, in a murine model of rheumatoid arthritis induced by collagen type II, Khan et al. evidenced that this F. hepatica-derived molecule protects against cartilage loss and the architecture destruction.

  • Advances in asthma in 2017: Mechanisms, biologics, and genetics

    2018, Journal of Allergy and Clinical Immunology
    Citation Excerpt :

    The products of this response might have a clinical application. Tanaka et al89 examined a peptide secreted by an animal and human parasite, Fasciola hepatica. The peptide Fasciola hepatica helminth defense molecule 1 (FhHDM-1) has potential anti-inflammatory properties.

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A.T. is supported by an Australian Government Research Training Program Scholarship. V.S.R.R.A. is supported by a University of Technology Sydney Postgraduate Research Scholarship. N.T. is supported by the Swiss National Science Foundation (grant P300PA_164715). C.T. and S.W. are supported by the Medical Research Council. J.P.D. is funded by grants from a European Research Council Advanced Grant (HELIVAC, 322725) and is a member of the Horizon 2020-funded Consortium PARAGONE. S.D. is funded by the National Health and Medical Research Council Australia (APP1087341).

Disclosure of potential conflict of interest: S. Donnelly and J. Dalton are both named inventors on a patent application covering the use of FhHDM-1 as an immune-modulating agent. The rest of the authors declare that they have no relevant conflicts of interest.

These authors contributed equally to this work.

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