Environmental and occupational respiratory disordersCat and dust mite allergen levels, specific IgG and IgG4, and respiratory symptoms in adults
Section snippets
Methods
The methods for the European Community Respiratory Health Survey (ECRHS) I have been described elsewhere13, 14 and are also given in greater detail in this article's Online Repository at www.jacionline.org. Between 1998 and 2002, participants in ECRHS I in 22 centers (5 in Spain; 3 in Italy and Sweden; 2 in Belgium, the United Kingdom, France, Germany; 1 in Estonia, Iceland, and Switzerland) were recontacted and invited to visit a local clinic to complete a detailed questionnaire and have blood
Results
There were 2780 participants (1294 men and 1486 women) aged between 27 and 56 years (median, 44; interquartile range, 38-49) with serum cat specific IgE, IgG, and IgG4 measures and information on current cat ownership (2498 with mattress Fel d 1 level). There were 2572 subjects with IgE, IgG, and IgG4 to HDM and mattress Der 1 allergen measured. The number of subjects from each center and country are shown in this article's Table E2 in the Online Repository at www.jacionline.org.
The level of
Discussion
We have shown that in a community-based sample of adults, serum IgG and IgG4 to cat and to HDM can be detected in most subjects and, for cat, are higher in subjects exposed to cat allergen. We have found no evidence that exposure to high levels of cat allergen in the home is associated with a lower prevalence of IgE sensitization to cat, or that high levels of cat specific IgG or IgG4 are associated with a decreased risk of IgE sensitization or respiratory symptoms.
Participants in this study
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The coordination of ECRHS II was supported by the European Commission as part of their Quality of Life program. For funders of the data collection in each center, please see this article's Online Repository at www.jacionline.org.
Disclosure of potential conflict of interest: The authors have declared that they have no conflict of interest.
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Deceased.