Journal of the American College of Cardiology
Volume 56, Issue 25, 14–21 December 2010, Pages 2115-2125
Pre-Clinical ResearchCannabidiol Attenuates Cardiac Dysfunction, Oxidative Stress, Fibrosis, and Inflammatory and Cell Death Signaling Pathways in Diabetic Cardiomyopathy
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Key Words
cannabinoids
diabetic complications
inflammation
oxidative stress
Abbreviations and Acronyms
ADP
adenosine diphosphate
CBD
cannabidiol
HCM
human cardiomyocytes
HG
high glucose
HNE
hydroxynonenal
ICAM
intercellular adhesion molecule
IκB-α
inhibitor of nuclear transcription factor nuclear factor-κB
iNOS
inducible nitric oxide synthase
JNK
c-Jun N-terminal kinase
MAPK
mitogen-activated protein kinase
MMP
matrix metalloproteinase
NADPH
nicotinamide adenine dinucleotide phosphate
NF-κB
nuclear factor kappa B
NT
nitrotyrosine
PARP
poly(ADP-ribose) polymerase
ROS
reactive oxygen species
SOD
superoxide dismutase
THC
delta 9-tetrahydrocannabinol
TNF
tumor necrosis factor
TUNEL
terminal deoxynucleotidyl transferase dUTP nick end labeling
VCAM
vascular cell adhesion molecule
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Drs. Rajesh and Partha Mukhopadhyay contributed equally to this article. This study was supported by the Intramural Research Program of the NIH/NIAAA (to Dr. Pacher) and NIDA Grant DA9789 (to Dr. Mechoulam). Dr. Horváth is a recipient of a Hungarian Research Council Scientific Research Fund Fellowship (NKTH-OTKA-EU, MB08-80238). Dr. Veves receives funding from Novartis for an investigator-initiated research grant, unrelated to this study. Dr. Mechoulam is a consultant for GW Pharmaceuticals, United Kingdom, which is not involved in this publication and is unaware of it. All other authors have reported that they have no relationships to disclose.
Copyright © 2010 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.