Preclinical ResearchApolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs
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Supported by grants from The Danish Heart Association, Copenhagen, Denmark, The Novo Nordisk Foundation, Hellerup, Denmark, The Lundbeck Foundation, Copenhagen, Denmark, The Danish Council for Independent Research—Technology and Production Sciences, Copenhagen, Denmark, and Graduate School of Health, Aarhus University, Aarhus, Denmark. The CNIC is supported by the Spanish Ministry of Economy, Industry and Competitiveness (MINECO) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (MINECO award SEV-2015-0505). Aarhus University owns a patent on porcine APOE targeting with Drs. Bentzon, Sørensen, and Bolund listed as inventors (EP 2134847). Drs. Sørensen, Callesen, and Bolund are members of the EU COST Action BM1308 “Sharing advances on large animal models—SALAAM.” Dr. Bolund is the Chief Scientific Officer of PixieGene. Drs. Bentzon and Sørensen contributed equally to this work.
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