Journal of the American Academy of Child & Adolescent Psychiatry
New researchLongitudinal Associations Between Sleep Patterns and Psychiatric Symptom Severity in High-Risk and Community Comparison Youth
Section snippets
Sample
Previous reports provide a detailed description of the methods of BIOS.20 All study procedures were approved by the University of Pittsburgh Institutional Review Board. Parents with DSM-IV bipolar disorder (BP; types I and II) living within 200 miles of Pittsburgh were recruited through advertisements, research studies, and outpatient clinics. Comparison parents were recruited from the community using random-digit dialing and matched to the parents with BP by age, sex, and neighborhood.
Lasso Regression
Lasso regression identified two demographic features, three clinical variables, and five sleep patterns with non-zero coefficients predicting change in the five psychiatric symptoms from baseline through follow-up (Table 3, Figure 1). These predictors explained 16.0% of the variance in the multivariate psychiatric symptom change score outcome.
Discussion
Lasso regression identified associations between sleep patterns and longitudinal changes in five psychiatric symptom severity measures (mania, depression, anxiety, mood lability, and inattention/ externalizing) in BIOS youth. Over an average of 3.8 years, changes in these psychiatric symptom severities paralleled changes across follow-up in a combination of shorter sleep duration, later sleep timing preference, poorer sleep continuity, and worsening daytime sleepiness. Sleep patterns accounted
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2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Individuals with BD further exhibit a delayed circadian phase, favouring a late bed and rise-time (Melo et al., 2016), along with hypersensitivity to evening light (Geoffroy, 2018). Sleep and circadian disruptions in BD are associated with increased suicidality (Palagini et al., 2019) and a range of psychosocial (Morton and Murray, 2020; Bradley et al., 2017) and cognitive impairments (Bradley et al., 2020; Kanady et al., 2017), as well as episode relapse (Soehner et al., 2019; Cretu et al., 2016). Beyond their role as symptoms, sleep and circadian rhythms might also be causal factors in BD.
This work was supported by National Institute of Mental Health (NIMH) grants R01MH060952 (Drs. Birmaher and Phillips) and K01MH111953 (Dr. Soehner).
Drs. Soehner, Phillips, and Birmaher had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Pittsburgh Bipolar Offspring Study (BIOS) concept and design: T.R. Goldstein, Axelson, B. Goldstein, Diler, Birmaher. Acquisition, analysis, or interpretation of data: Soehner, Bertocci, Levenson, Merranko, Rooks, Hafeman, T.R. Goldstein, Axelson, Monk, Hickey, Diler, Phillips, Birmaher. Drafting of the manuscript: Soehner, Bertocci, Levenson. Critical revision of the manuscript for important intellectual content: Soehner, Bertocci, Levenson, Hafeman, Merranko, T.R. Goldstein, B. Goldstein, Phillips, Birmaher. Statistical analysis: Soehner, Bertocci, Merranko. Obtained funding: Phillips, Birmaher. Administrative, technical, or material support: Axelson, Monk, Hickey, Diler, Birmaher. BIOS supervision: T.R. Goldstein, Axelson, Diler, Birmaher.
Drs. Phillips and Birmaher are co−senior authors of this article.
Dr. Bertocci and Mr. Merranko served as the statistical experts for this research.
The authors wish to thank Erin Rodgers, BS, of the University of Pittsburgh, for assistance with manuscript preparation along with Satish Iyengar, PhD, and Kehui Chen, PhD, of the University of Pittsburgh, for their input on earlier versions of this statistical analysis.
Disclosure: Dr. Soehner has received grant funding from the NIMH and the Klingenstein Third Generation Foundation (KTGF). Dr. Levenson has received grant funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD). Dr. T. Goldstein has received grant funding from the NIMH, the Brain and Behavior Research Foundation, and the American Foundation for Suicide Prevention and has received royalties from Guilford Press. Dr. Hafeman has received grant funding from the KTGF and NIMH. Dr. Diler has received grant funding from the NIMH. Dr. Axelson has served as a consultant to Janssen Research, has received grant support from Neuronetics, and has or will receive royalties from UpToDate. Dr. B. Goldstein has received grant or research support from the Canadian Institutes of Health Research, the Brain and Behavior Research Foundation (NARSAD), the Ontario Ministry of Research and Innovation, the Ontario Mental Health Foundation, the Heart and Stroke Foundation of Canada, and Brain Canada. Dr. Phillips has received grant funding from the NIMH. Dr. Birmaher has received grant funding from the NIMH, has or will receive royalties from American Psychiatric Publishing, Random House, Lippincott Williams and Wilkins, and UpToDate, and has served as a consultant to Janssen Research. Drs. Bertocci and Rooks, Mr. Merranko, and Mss. Hickey and Monk report no biomedical financial interests or potential conflicts of interest.