iScience
Volume 7, 28 September 2018, Pages 154-169
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Review
The Systems Biology of Single-Cell Aging

https://doi.org/10.1016/j.isci.2018.08.023Get rights and content
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Aging is a leading cause of human morbidity and mortality, but efforts to slow or reverse its effects are hampered by an incomplete understanding of its multi-faceted origins. Systems biology, the use of quantitative and computational methods to understand complex biological systems, offers a toolkit well suited to elucidating the root cause of aging. We describe the known components of the aging network and outline innovative techniques that open new avenues of investigation to the aging research community. We propose integration of the systems biology and aging fields, identifying areas of complementarity based on existing and impending technological capabilities.

Subject Areas

Gerontology
Biological Sciences
Systems Biology
Complex Systems

Cited by (0)

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These authors contributed equally